吴缅，中国科学技术大学生命科学学院教授，博士生导师。中科院百人计划引进人才。1953年1月生，江苏苏州市人。1982年本科毕业于南京师范大学生物系，1984年获美国哥伦比亚大学生物化学硕士，1988年获哥伦比亚大学分子生物学博士，1988-1990美国哈佛大学细胞发育系的博士后。

1982年本科毕业于南京师范大学生物系；

1984年获美国哥伦比亚大学生物化学硕士；

1988年获哥伦比亚大学分子生物学博士；

1988-1990美国哈佛大学细胞发育系的博士后。

1991-1995新加坡大学生物学系担任助理教授；

1996-1998新加坡中央医院神经内科基因治疗组高级研究员；

1、 肿瘤细胞凋亡/生存的分子机制，实验室集中研究的蛋白有:肿瘤抑制因子P53和ARF等; 凋亡诱导因子Siah-1、bad等以及抗肿瘤因子Pirh2等。我们实验室感兴趣的是各个分子之间的“对话（cross-talk）”以及由此产生的细胞功能。

2、 蛋白质的翻译后修饰，尤其是蛋白质磷酸化和泛素化修饰，我们对Survivin-△Ex3、Siah-1/Siah1S、Pirh2以及P53的磷酸化及泛素化研究有较为深入的研究

3、 除了线粒体凋亡途径以及受体凋亡途径外，我们实验室主要集中在细胞核凋亡信号网络的研究，我们发现Caspase-8的激活以及Pirh2的磷酸化都与细胞核紧密相联

4、 肿瘤对药物的抗性与细胞凋亡机制的损坏密切相关，实验利用Microarray找到了一些novel 的抗紫杉醇的基因，正在研究这些上调或下调的基因在抗紫杉醇中的分子机理。

2000年，中国科学技术大学生命科学学院“百人计划”教授、博士生导师。承担过国家973项目4项，任课题组长。2006年以来，连续三次承担国家基金委重点项目，并承担中科院先导项目子课题负责人。多年来，在肿瘤细胞凋亡/生存的信号转导及分子机制，非编码RNA调控肿瘤发生发展的分子机理，p53与细胞代谢及诱导性多能干细胞调控的分子机制方面做了一些开创性的工作。在SCI杂志上发表论文60多篇，包括在国际上具有重要影响力的期刊，如Nature Cell Biology，Molecular Cell, Nature Communications,PNAS, 和EMBO Journal等.被引用超过2900次。

1科技部“973”一级子课题：细胞凋亡调控蛋白质作用网络的研究（2002CB713702）2002- 2007

2.国家自然科学基金委员会重点项目：细胞核在细胞凋亡过程中的信号转导及其分子机制的研究（30530200）2006.10-2009.12

3.中国科学院知识创新工程重要方向项目：真核细胞的核仁在肿瘤发生和细胞凋亡信号调控网络中的功能研究 (KSCX1-YW-R-57) 2006-2009

(1) Shanshan Duan, Zhan Yao, Dezhi Hou, Zhengsheng Wu, Wei-guo Zhu and Mian Wu* Phosphorylation of Pirh2 by Calmodulin-dependent kinase II impairs its ability to ubiquitinate p53. EMBO J, 2007 Jul 11;26(13):3062-74.

(2) Zhan Yao, Shanshan Duan, Dezhi Hou, Klaus Heese and Mian Wu*. Death effector domain DEDa, a self-cleaved product of Caspase-8/Mch5,translocates to the nucleus by binding to ERK1/2 and up-regulates procaspase-8 expression via a p53-dependent mechanism. EMBO J, 2007 Feb 21;26(4):1068-80

(3) Jiang P, Du W, Heese K, Wu M*.The Bad Guy Cooperates with Good Cop p53: Bad Is Transcriptionally Up-Regulated by p53 and Forms a Bad/p53 Complex at the Mitochondria To Induce Apoptosis. Mol Cell Biol. 2006 Dec;26 (23):9071-9082

(4) Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M*. Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. Cell Death Differ. 2006 Dec;13 (12):2079-88

Zhiyin Song and Mian Wu. (2004) Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene (in press).

Yang Y, Ma J, Chen Y, Wu M. (2004) Nucleocytoplasmic shuttling of RIP3: Identification of novel nuclear export and import signals in RIP3. J Biol Chem. 279: 38820-38829

Hoti N, Zhu DE, Song Z, Wu Z, Tabassum S, Wu M. (2004) p53-dependent apoptotic mechanism of a new designer bimetallic compound Tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): In vivo studies in Wistar rats as well as in vitro studies in human cervical cancer cells. J Pharmacol Exp Ther. 311:22-33

Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem. 15;279(42):43716-24.

Wang J, Chen J, Wu M. Expression and characterization of human tumor necrosis factor-related apoptosis inducing ligand in methylotrophic yeast Pichia pastoris. Ital J Biochem. 2004 Jul;53(2):67-72.

Zhiyin Song, Shixin Liu, He He, Naser Hoti, Yi Wang, Shanshan Feng and Mian Wu (2004). A Single Amino Acid Change(Asp 53→Ala 53) Converts Survivin from Anti-apoptotic to Pro-apoptotic. Mol. Biol. Cell. 15(3):1287-96.

Lin Miao, Peng Yi, Yi Wang and Mian Wu (2003). Etoposide upregulates Bax enhancing tumor necrosis factor-related apoptosis-inducing ligand mediated apoptosis in Human hepatocellular carcinoma cell line QGY-7703. Eur. J. Biochem. 270 (13), 2721-2731

N. Hoti, J. Ma, S Tabasum, Y. Wang and M. Wu (2003). Triphenyl tin benzimidazolethiol, a novel antitumor agent induces mitochondrial-mediated apoptosis in human cervical cancer cells via suppression of HPV-18 encoded E6. J. Biochem. 134 (521-528).

Zhiyin Song, Xue B Yao, and Mian Wu (2003). Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis. J. Biol.Chem. 278(25):23130-40

Peng Yi, Wei Zhang, Zhiwei Zhai, Lin Miao, Yi Wang and Mian Wu (2003). Bcl-rambo beta, a special splicing variant with an insertion of Alu-like cassette, promotes etoposide and Taxol induced cell death. FEBS Letters 534 (61-68)

Yonghui Yang, Jun Ma, Zhiyin Song, Mian Wu (2002). HIV-1 TAT mediated protein transduction and subcellular localization using novel expression vectors. FEBS Letters 532 (36-44)

B. Ren, N Hoti, X Rabasseda, Y Z Wang and M Wu.(2003) The Antiangiogenic and Thera peutic Implications of Endostatin. Method Find. Exp. Clin. Pharmacol. 25(3) 215-224

Yang Y, Xu c, Ge F, Lu Z, Zhu G, Li H, Liao J, Niu L, Wang Y, Wu M (2002). Site-specific integration of the double-mutation glucose isomaase (GIG138 PG247 D) gene in streptomyces lividans and its stable expression. Curr. MicrobioL. Jan 44(1):18-24.

Mian Wu, Das Asha,Tan Yan, Das asha, Cong-ju Zhu, Taian Cui and Meng Cheong Wong (2000) : TRAIL/Apo2L induces apoptosis in human glioma cells. J. Neurosci. Res 61:464-470

Colby Geoffrey, Mian Wu and Tzagoloff Alexander:(1998) MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae J. Biol Chem 273, 27945-27952

Tzagoloff, J. Jang, D.M.Glerum and M. Wu FLX1 codes for a carrier protein involved in maintaining a proper balance of Flavin Nucleotide in yeast mitochondria J. Biol. Chem (1996) 271 7792-7797

M. Wu, B. Repetto, M. Glerium and A. Tzagoloff. Cloning and characterization of FAD1, the structural gene for Flavin Dinucleotide Synthetase of Saccharomyces cerevisiae. Mol. Cell. Biol. (1995) 15, 264-271.