吴蓓丽，女，汉族，1979年1月生，研究生，理学博士，2012年9月加入民盟。现任中国科学院上海药物研究所研究员、课题组长，民盟上海市委副主委、民盟中国科学院上海分院委员会主委。

1979年1月，吴蓓丽出生于河南南召，原籍江苏吴江。

1994年9月—1997年7月，高中就读于江苏省无锡市第一中学。

1997年9月—2001年7月，就读于北京师范大学生物系生物化学专业，毕业并获得学士学位。

2001年9月—2006年6月，就读于清华大学生物科学与技术系生物物理学专业，师从结构生物学专家饶子和院士，毕业并获得博士学位。

2007年4月—2011年7月，在美国斯克利普斯研究所（Scripps Research）分子生物学系从事博士后研究工作。

2011年7月，入选中国科学院百人计划，回国后担任中国科学院上海药物研究所药物靶标结构与功能中心研究员、课题组长。

2012年9月，加入中国民主同盟；同年，入选上海市“浦江人才计划”，并被聘为国家重点基础研究发展计划（973计划）课题负责人。

2014年，获得国家自然科学基金“优秀青年科学家基金项目”资助。

2018年8月，获得国家杰出青年科学基金资助；同年，入选中组部“万人计划”青年拔尖人才、科技创新领军人才。

现任中国科学院上海药物研究所研究员、课题组长，民盟上海市委副主委、民盟中国科学院上海分院委员会主委。

吴蓓丽主要针对重要药物靶标蛋白家族G蛋白偶联受体（GPCR）开展结构与功能研究，并进行基于结构的药物研发。通过测定GPCR与不同类型配体及下游效应蛋白的复合物三维结构，阐明不同GPCR对配体的选择性识别模式及信号的特异性转导机制，为靶向GPCR的药物研发提供线索和依据。

根据2024年1月中国科学院上海药物研究所网站数据，吴蓓丽先后在学术期刊Nature、Science和Cell发表13篇研究论文。

Qiuxiang Tan#, Ya Zhu#, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, Xin Xie, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex [J]. Science 341:1387-1390, 2013.

Kaihua Zhang#, Jin Zhang#, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu & Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug [J]. Nature 509:115-118, 2014.

Jin Zhang#, Kaihua Zhang#, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* & Qiang Zhao*. Agonist-bound structure of the human P2Y12 receptor [J]. Nature 509:119-122, 2014.

Dandan Zhang, Zhan-Guo Gao, Kaihua Zhang, Evgeny Kiselev, Steven Crane, Jiang Wang, Silvia Paoletta, Cuiying Yi, Limin Ma, Wenru Zhang, Gye Won Han, Hong Liu, Vadim Cherezov, Vsevolod Katritch, Hualiang Jiang, Raymond C. Stevens, Kenneth A. Jacobson, Qiang Zhao* & Beili Wu*. Two disparate ligand binding sites in the human P2Y1 receptor [J]. Nature 520:317-321, 2015.

Haonan Zhang#, Anna Qiao#, Dehua Yang#, Linlin Yang#, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang*, Ming-Wei Wang* & Beili Wu*. Structure of the full-length glucagon class B G protein-coupled receptor [J]. Nature 546:259-264, 2017.

Haonan Zhang, Anna Qiao, Linlin Yang, Ned Van Eps, Klaus S. Frederiksen, Dehua Yang, Antao Dai, Xiaoqing Cai, Hui Zhang, Cuiying Yi, Can Cao, Lingli He, Huaiyu Yang, Jesper Lau, Oliver P. Ernst, Michael A. Hanson, Raymond C. Stevens, Ming-Wei Wang, Steffen Reedtz-Runge, Hualiang Jiang, Qiang Zhao* & Beili Wu*. Structure of the glucagon receptor in complex with a glucagon analogue [J]. Nature 553:106-110, 2018.

Zhenlin Yang#, Shuo Han#, Max Keller#*, Anette Kaiser#, Brian J. Bender#, Mathias Bosse, Kerstin Burkert, Lisa M. Kogler, David Wifling, Guenther Bernhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, Beibei Li, Sheng Ye, Rongguang Zhang, Bo Xu, Dan Larhammar, Raymond C. Stevens, Daniel Huster, Jens Meiler, Qiang Zhao, Annette G. Beck-Sickinger*, Armin Buschauer & Beili Wu*. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor [J]. Nature 556:520-524, 2018.

Can Cao#, Qiuxiang Tan#, Chanjuan Xu, Lingli He, Linlin Yang, Ye Zhou, Yiwei Zhou, Anna Qiao, Minmin Lu, Cuiying Yi, Gye Won Han, Xianping Wang, Xuemei Li, Huaiyu Yang, Zihe Rao, Hualiang Jiang, Yongfang Zhao, Jianfeng Liu, Raymond C. Stevens, Qiang Zhao, Xuejun C. Zhang* and Beili Wu*. Structural basis for signal recognition and transduction by platelet-activating-factor receptor [J]. Nature Structural & Molecular Biology 25:488-495, 2018.

Hengxin Fan#, Shuanghong Chen#, Xiaojing Yuan, Shuo Han, Hui Zhang, Weiliang Xia, Yechun Xu, Qiang Zhao* and Beili Wu*. Structural basis for ligand recognition of the human thromboxane A2 receptor. Nature Chemical Biology 15:27-33, 2019.

Shuanghong Chen#, Mengjie Lu#, Dongsheng Liu#, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu*, Kurt Wuthrich* & Qiang Zhao*. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography [J]. Nature Communications 10:638, 2019.

Tong Chen#, Muya Xiong#, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu*, Qiang Zhao* & Beili Wu*. Structural basis of ligand binding modes at the human formyl peptide receptor 2 [J]. Nature Communications 11(1):1208, 2020.

Anna Qiao#, Shuo Han#, Xinmei Li#, Zhixin Li#, Peishen Zhao#, Antao Dai, Rulve Chang, Linhua Tai, Qiuxiang Tan, Xiaojing Chu, Limin Ma, Thor Seneca Thorsen, Steffen Reedtz-Runge, Dehua Yang, Ming-Wei Wang, Patrick M. Sexton, Denise Wootten*, Fei Sun*, Qiang Zhao*, Beili Wu*. Structural basis of Gs and Gi recognition by the human glucagon receptor [J]. Science 367:1346-1352, 2020.

Tingting Tang#, Christin Hartig#, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao*, Annette G. Beck-Sickinger* & Beili Wu*. Structural basis for ligand recognition of the neuropeptide Y Y2 receptor [J]. Nature Communications 12:737, 2021.

Shuling Lin#, Shuo Han#, Xiaoqing Cai#, Qiuxiang Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, Cuiying Yi, Xiaojing Chu, Antao Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang*, Qiang Zhao* & Beili Wu*. Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4 [J]. Nature 594:583-588, 2021.

Juan Du#, Dejian Wang#, Hongcheng Fan#, Chanjuan Xu#, Linhua Tai#, Shuling Lin#, Shuo Han, Qiuxiang Tan, Xinwei Wang, Tuo Xu, Hui Zhang, Xiaojing Chu, Cuiying Yi, Peng Liu, Xiaomei Wang, Yu Zhou, Jean-Philippe Pin, Philippe Rondard, Hong Liu*, Jianfeng Liu*, Fei Sun*, Beili Wu* & Qiang Zhao*. Structures of human mGlu2 and mGlu7 homo- and heterodimers [J]. Nature 594:589-593, 2021.

Hui Zhang#, Kun Chen#, Qiuxiang Tan#, Qiang Shao#, Shuo Han#, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu*, Yechun Xu*, Qiang Zhao*, Beili Wu*. Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 [J]. Nature Communications 12:4151, 2021.

Xuefeng Zhang#, Chenglin He#, Mu Wang#, Qingtong Zhou#, Dehua Yang#, Ya Zhu#, Wenbo Feng, Hui Zhang, Antao Dai, Xiaojing Chu, Jia Wang, Zhenlin Yang, Yi Jiang, Ulrich Sensfuss, Qiuxiang Tan, Shuo Han, Steffen Reedtz-Runge, Eric H. Xu, Suwen Zhao*, Ming-Wei Wang*, Beili Wu*, Qiang Zhao*. Structures of the human cholecystokinin receptors in complex with agonists and antagonists [J]. Nature Chemical Biology 17:1230-1237, 2021.

Ya Zhu#, Xiaowen Lin#, Xin Zong#, Shuo Han#, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao*, Beili Wu*. Structural basis of FPR2 in recognition of Ab42 and neuroprotection by humanin [J]. Nature Communications 13:1775, 2022.

Xiangli Qu#, Na Qiu#, Mu Wang#, Bingjie Zhang#, Juan Du, Zhiwei Zhong, Wei Xu, Xiaojing Chu, Limin Ma, Cuiying Yi, Shuo Han, Wenqing Shui*, Qiang Zhao* & Beili Wu*. Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1 [J]. Nature 604:779-785, 2022.

吴蓓丽为抗艾滋病毒新药研发作出了突出贡献。（树森兰娟院士人才基金评）

吴蓓丽委员积极履职尽责践行政协委员职能，为生物医药领域传递了积极的声音、贡献了众多的智慧。（时任上海市政协副主席寿子琪评）