巨勇,
清华大学生命有机磷化学及化学生物学教育部重点实验室副主任。
清华大学化学系,副教授(1995-2003),教授(2003-)。
人物经历
教育背景
1982年,理学学士,兰州大学化学系
1987年,理学硕士,兰州大学化学系
1992年,理学博士,兰州大学化学系
工作经历
1982-1993兰州大学化学系,助教,讲师。
1996-1998美国Rutgers大学植物系,访问学者。
2001-2002美国Ohio州立大学化学系,高级访问学者。
2005-2006美国South Carolina大学化学与生物化学系,访问教授。
社会任职
第十届北京市政协委员。
《Pharmazie》编委(2006-)。
研究方向
主要研究领域
生物活性天然产物的结构,化学修饰,生物转化和构效关系
生物小分子的化学进化及其仿生机理
糖生物缀合物、磷酰化肽、肽库等的化学合成及其生物学功能
主讲课程
本科生:有机化学,有机合成设计,天然产物化学。
研究生:立体有机化学,天然有机化学。
研究成果和获得奖励
作为课题负责人和主要工作者,先后承担完成国家自然科学基金“七.五”重大项目和“八.五”重点项目各1项,主持
国家自然科学基金项目3项。
荣获教育部自然科学奖二等奖1项(2003),国家教委科技进步奖二等奖(1995),三等奖(1997)各1项,甘肃省科技进步奖二等奖1项(1993)。
主编出版《
有机合成化学与路线设计》(
清华大学出版社,2002)。《磷与生命化学》(清华大学出版社,第8章,2005)。《
现代有机合成试剂》(
化学工业出版社,2006)。
在国内外重要学术刊物上发表研究论文90余篇。
出版图书
合作单位
美国 New Jersey State Rutgers University 植物系
美国 Ohio State University 化学系
美国 University of South Carolina 化学与生物化学系
兰州大学功能有机分子化学国家重点实验室
国际学术交流
第四届国际杂原子学术大会(口头报告,韩国:汉城,1995.8.4-8.7)。
美国 Rutgers 大学植物系合作研究 (1996.9-1998.3)。
美国 Ohio 州立大学化学系合作研究 (2001.7-2002.7)。
第225届美国化学会年会、顺访(口头报告,美国:新奥尔良;Ohio州立大学,2003.3.22-4.5)。
发表论文
1. Ji SH,Xiao Q,Ju Y(巨勇),Zhao YF,Synthesis of novel dimeric steroidal nucleoside phosphoramidates,Chemistry Letters,2005,34⑺,944-945.
2. Liu MJ,Wang Z,Ju Y(巨勇),Wong RNS,Wu QY. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology, 2005,55⑴,79-90.
3. Liu MJ,Wang Z,Ju Y(巨勇),Zhou JB,Wang Y,Wong RNS,The Mitotic-Arresting and Apoptosis-Inducing Effects of Diosgenyl Saponins on Human Leukemia Cell Lines. Biological & Pharmaceutical Bulletin. 2004,27 ⑺1059-1065.
4. Li HY,Byeon IJL,Ju Y(巨勇),Tsai MD,Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions,Journal of Molecular Biology,2004,335⑴,371-381.
5. Tan B,Lee MC,Cui M,Liu T,Chen ZZ,Li YM,Ju Y(巨勇),Zhao YF,Chen KX,Jiang HL,A common intermediate for prebiotic synthesis of proteins and nucleosides: a density functional theory (DFT) study on the formation of penta-coordinate phosphorus carboxylic–phosphoric mixed anhydride from N-phosphoryl amino acids,Journal of Molecular Structure (Theochem) 2004,672,51–60.
6. Xiao Q,Sun J,Sun Q,Ju Y(巨勇),Zhao YF,Cui YX,Synthesis of AZT 5’-O-Hydrogen phospholipid and their derivatives,Synthesis-Stuttgart,2003,⑴,107-111.
7. Xiao Q,Ju Y(巨勇),Yang XP,Zhao YF,Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids,Rapid Communications in Mass Spectrometry,2003,17⒀,1405–1410
8. Wang SF,Ju Y(巨勇),Chen XG,Hu ZD,Separation and determination of coumarins in the root bark of three Citrus plants by micellar electrokinetic capillary chromatography,Planta Medica,2003,69⑸,483-486
9. Xiao Q,Ju Y(巨勇),Zhao YF,A facile approach to phosphonic acid diesters,Heteroatom Chemistry,2003,14⑶,208-210.
10. Qin ZH,Lin CX,Ju Y(巨勇),Zhao YF,Synthesis of serine/alanine conjugated 3’,5’- TpT,Nucleosides,Nucleotides & Nucleic Acids,2003,22⑴,63-69.
11. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Facile synthesis of 3β-cholesterol H-phosphonates,Chemistry Letters,2003,32⑹,522-523.
12. Xiao Q,Ju Y(巨勇),Zhao YF,One-pot Synthesis of the H-phosphonate of AZT and diosgenin,Chemical Journal of Chinese Universities,2003,24⑻,1427-1429 (in Chinese).
13. Xiao Q,Ju Y(巨勇),Zhao YF,A convenient route to symmetric phosphate,phosphorothioate and phosphoroselenoate of AZT and D4T,Synthetic Communications,2003,33(23),4157-4162.
14. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Facile synthesis of bivalent ligand-based phosphoramidates of AZT,Journal of Chemical Research,2003,⑸,262-263.
15. Xiao Q,Ju Y(巨勇),Zhao YF,Cui YX,Characteristic fragmentation behavior of phosphoamino acid conjugates with 3’-azido-3’ -deoxythymidine by electrospray ionization tandem mass spectrometry,Rapid Communications in Mass Spectrometry,2003,17⒇,2273-2278.
16. Wang SF,Chen XG,Hu ZD,Ju Y(巨勇),Analysis of three effective components in Fructus corni and its preparations by micellar electrokinetic capillary chromatography,Biomedical Chromatography,2003,17⑸,306-311.
17. Wang SF,Wu YQ,Ju Y(巨勇),Chen XG,Zheng WJ,Hu ZD,On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of flavonoids in Epimedium brevicornum Maxim,Journal of Chromatography A,2003,1017 (1-2),27-34.
18. Qin DY,Lee H,Yuan CH,Ju Y(巨勇),Tsai MD,Identification of Potential Binding Sites for the FHA Domain of Human Chk2 by in vitro Binding Studies,Biochemical & Biophysical Research Communications,2003,311 ⑷,803-808.
19. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Novel approach to the synthesis of AZT 5’-O-hydrogen phospholipids,Tetrahedron Letters,2002,43(30),5281-5283.
20. Qin ZH,Lin CX,Chen Y,Ju Y(巨勇),Zhao YF,Electrospray ionization mass spectrometry of serine/alanine conjugated 5’-UMP and 3’,5’-dithymidine phosphoramidates,Rapid Communications in Mass Spectrometry,2002,16,1997-2002.
21. Cai J,Liu MJ,Wang Z,Ju Y(巨勇),Apoptosis induced by dioscin in hela cells,Biological Pharmaceutical Bulletin,2002,25⑵,193-196.
22. Ju Y(巨勇),Still CC,Sacalis JN,Li J and Ho CT,Cytotoxic coumarins and lignans from extracts of the northern prickly ash,Phytotherapy Research,2001,15,441-443.
23. Hu JJ,Ju Y(巨勇),Zhao Y F,Stereo effect of the peptide formation reaction of N- (O,O-diisopropyl) phosphoryl serine,Chemical Journal Chinese Universities,2001,22⑶,399-402 (in Chinese).
24. Wang Z,Zhou JB,Ju Y(巨勇),Zhang H,Liu MJ,Li X,Effects of two saponins extracted from the Polygonatum zanlanscianense on the human leukemia (HL-60) cells,Biological Pharmaceutical Bulletin,2001,24⑵,159-162.
25. Ju Y(巨勇),Hu JJ,Zhao YF,Reaction of carbohydrates and pentacoordinate oxaphosphorane and their biomimetic mechanism,Phosphorus,Sulfur,Silicon and other Element,2000,167,93-100.
26. Hu JJ,Ju Y(巨勇),Zhao YF,Novel synthesis of tri- and penta-coordinate phosphorous saccharides,Synthetic Communication,2000,30 (22),4087-4092.
27. Hu JJ,Ju Y(巨勇),Zhao YF,LC-MS analysis of the formed peptides from N- (O,O-diisoprpyl) phosphoryl aspartic acid,Chinese Journal of Chemistry,2000,18⑹,932-935.
28. Hu JJ,Ju Y(巨勇),Zhao YF,Studies on reaction of between N-phosphoryl amino acids and ribotides,Chemical Journal of Chinese Universities,2000,21⑾,1667-1670 (in Chinese).