希腊拉丁方阵（Graeco-Latin square）是两个拉丁方阵相正交所得到的方阵。

它跟数独一样，每一行、每一列都不会重复，并且每一个拉丁字母与每一希腊字母只配对一次，就称这两方阵互为正交(orthogonal)，叠合后的方阵称为希腊拉丁方阵，拉丁方阵 n orders 就有 n-1 个正交方阵(orthogonal square)。

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Graeco-Latin square designs are sometimes useful to eliminate more than two sources of vaiability in an experiment. A Graeco-Latin design is an extension of the Latin sqare design, but one extra blocking variable is added for a total of three blocking variables.