李昂，男，汉族，1982年6月生，群众，中国科学院上海有机化学研究所研究员。

2000.09-2004.06 北京大学化学与分子工程学院，理学学士，导师：杨震教授。

2004.07-2009.11 The Scripps Research Institute，California，USA，Ph.D.，导师：Prof. K. C. Nicolaou。

2010.01-2010.09 Institute of Chemical and Engineering Sciences，Singapore，research fellow，导师：Prof. K. C. Nicolaou。

2010.09-2019.11中国科学院上海有机化学研究所研究员。

2019.11- 中国科学院上海有机化学研究所副所长。

活性天然产物的化学合成

天然产物合成对化学学科的发展和小分子药物的创制起到了重要推动作用，是国际上非常活跃的研究领域。李昂博士在此领域取得了具有国际影响力的成绩，系统地发展了针对拥挤环系的合成策略，完成了14类90多个天然产物的全合成，其中45个为首次合成。他的一项代表性工作是虎皮楠生物碱的全合成。这类分子在过去30多年里引起了国际全合成界的广泛关注和激烈竞争。他完成了该家族多个成员的集合式合成，其中含有11个环和19个手性中心的hybridaphniphylline B的合成代表了该领域继Heathcock杰出工作后的一项突破。

2022年11月，荣获第十七届中国青年科技奖。

2020 第二届“科学探索奖”获得者

2017 Asian International Symposium Distinguished Lectureship Award, Chemical Society of Japan

2017 Tetrahedron Young Investigator Award for Organic Synthesis

2016 CAPA Distinguished Faculty Award

2016 ChemComm Emerging Investigator Lectureship

2015 The National Science Fund for Distinguished Young Scholars

2015 WuXi PharmaTech Life Science and Chemistry Award

2015 Roche Chinese Young Investigators Award

2013 Asian Core Program Lectureship Award

2013 Chinese Chemical Society Wei-Shan Award for Synthetic Chemistry

2013 China Pharmaceutical Association–Servier Youth Medicinal Chemist Award

2013 Thieme Chemistry Journal Award

2012 Asian Core Program Lectureship Award

2009 Eli Lilly Graduate Fellowship

2007 Chinese Government Award for Outstanding Graduate Students Abroad

2007 Bristol-Myers Squibb Graduate Fellowship in Organic Synthesis

(1) P. Yang, J. Li, L. Sun, M. Yao, X. Zhang, W.-L. Xiao, J.-H. Wang, P. Tian,* H.-D. Sun,* P.-T. Puno,* A. Li,* Elucidation of the structure of pseudorubriflordilactone B by chemical synthesis. J. Am. Chem. Soc. 142 (2020), DOI: 10.1021/jacs.9b09699

(2) S. Zhou, K. Xia, X. Leng, A. Li,* Asymmetric total synthesis of arcutinidine, arcutinine, and arcutine. J. Am. Chem. Soc. 141 (2019), DOI: 10.1021/jacs.9b05818

(3) X. Zhang, B. N. Kakde, R. Guo, S. Yadav, Y. Gu, A. Li,* Total synthesis of echitamine, akuammiline, rhazicine, and pseudoakuammigine. Angew. Chem. Int. Ed. 58 (2019), DOI: 10.1002/anie.201901086

(4) Z. Lu, X. Zhang, Z. Guo, Y. Chen, T. Mu, A. Li,* Total synthesis of aplysiasecosterol A. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b05070

(5) S. Zhou, R. Guo, P. Yang, A. Li,* Total synthesis of septedine and 7-deoxyseptedine. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b03712

(6) W. Zhang, M. Ding, J. Li, Z. Guo, M. Lu, Y. Chen, L. Liu, Y.-H. Shen, A. Li,* Total synthesis of hybridaphniphylline B. J. Am. Chem. Soc. 140 (2018), DOI: 10.1021/jacs.8b01681

(7) Y. Chen, W. Zhang, L. Ren, J. Li, A. Li,* Total syntheses of daphenylline, daphnipaxianine A, and himalenine D. Angew. Chem. Int. Ed. 57(2018), DOI:10.1002/ange.201711482

(8) J. Li, W. Zhang, F. Zhang, Y. Chen, A. Li,* Total synthesis of daphniyunnine C (longeracinphyllin A). J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b09186

(9) Z. Zhang, J. Wang, J. Li, F. Yang, G. Liu, W. Tang, W. He, J.-J. Fu, Y.-H. Shen,* A. Li,* W.-D. Zhang,* Total synthesis and stereochemical assignment of delavatine A: Rh-catalyzed asymmetric hydrogenation of indene-type tetrasubstituted olefins and kinetic resolution through Pd-catalyzed triflamide-directed C−H olefination. J. Am. Chem. Soc. 139 (2017), DOI: 10.1021/jacs.7b01718

(10) H. Li, Q. Chen, Z. Lu, A. Li,* Total syntheses of aflavazole and 14-hydroxyaflavinine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b10880

(11) P. Yang, M. Yao, J. Li, Y. Li, A. Li,* Total synthesis of rubriflordilactone B. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201601915

(12) Y. Li, S. Zhu, J. Li, A. Li,* Asymmetric total syntheses of aspidodasycarpine, lonicerine, and the proposed structure of lanciferine. J. Am. Chem. Soc. 138 (2016), DOI: 10.1021/jacs.6b00764

(13) M. Yang, X. Yang, H. Sun, A. Li,* Total synthesis of ileabethoxazole, pseudopteroxazole, and seco-pseudopteroxazole. Angew. Chem. Int. Ed. 55 (2016), DOI:10.1002/ange.201510568

(14) Z. Lu, H. Li, M. Bian, A. Li,* Total synthesis of epoxyeujindole A. J. Am. Chem. Soc. 137 (2015), DOI: 10.1021/jacs.5b09198

(15) S. Zhou, H. Chen, Y. Luo, W. Zhang, A. Li,* Asymmetric total synthesis of mycoleptodiscin A. Angew. Chem. Int. Ed. 54 (2015), DOI: 10.1002/ange.201501021

(16) M. Yang, J. Li, A. Li,* Total synthesis of clostrubin. Nat. Commun. 6 (2015), DOI：10.1038/ncomms7445

(17) Z. Meng, H. Yu, L. Li, W. Tao, H. Chen, M. Wan, D. J. Edmonds, J. Zhong, A. Li,* Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families. Nat. Commun. 6 (2015), DOI:10.1038/ncomms7096

(18) J. Li, P. Yang, M. Yao, J. Deng, A. Li,* Total synthesis of rubriflordilactone A. J. Am. Chem. Soc. 136 (2014), DOI:10.1021/ja5092563

(19) Z. Lu, M. Yang, P. Chen, X. Xiong, A. Li,* Total synthesis of hapalindole-type natural products. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201406626

(20) Y. Sun, P. Chen, D. Zhang, M. Baunach, C. Hertweck, A. Li,* Bioinspired total synthesis of sespenine. Angew. Chem. Int. Ed. 53 (2014), DOI: 10.1002/anie.201404191

(21) J. Deng, S. Zhou, W. Zhang, J. Li, R. Li, A. Li,* Total synthesis of taiwaniadducts B, C, and D. J. Am. Chem. Soc. 136 (2014), DOI：10.1021/ja503972p

(22) Y. Sun, R. Li, W. Zhang, A. Li,* Total synthesis of indotertine A and drimentines A, F, and G. Angew. Chem. Int. Ed. 52 (2013), DOI: 10.1002/anie.201303334

(23) Z. Lu, Y. Li, J. Deng, A. Li,* Total synthesis of the Daphniphyllum alkaloid daphenylline. Nat. Chem. 5 (2013), DOI: 10.1038/nchem.1694

(24) M. Bian, Z. Wang, X. Xiong, Y. Sun, C. Matera, K. C. Nicolaou,* A. Li,* Total syntheses of anominine and tubingensin A. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja302765m

(25) J. Deng, B. Zhu, Z. Lu, H. Yu, A. Li,* Total synthesis of (–)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart. J. Am. Chem. Soc. 134 (2012), DOI:10.1021/ja211444m