迈克尔·霍尔（Michael N. Hall），瑞士巴塞尔大学科学家。

迈克尔·霍尔，瑞士巴塞尔大学科学家。

Böhm, R., Imseng, S., Jakob, R. P., Hall, M. N., Maier, T. and Hiller, S. (2021) ‘The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1’, Molecular Cell, 81(11), pp. 2403–2416.e5. doi: 10.1016/j.molcel.2021.03.031. edoc

Dimitrakopoulos, C., Hindupur, S. K., Colombi, M., Liko, D., Ng, C. K. Y., Piscuoglio, S., Behr, J., Moore, A. L., Singer, J., Ruscheweyh, H.-J., Matter, M. S., Mossmann, D., Terracciano, L. M., Hall, M. N. and Beerenwinkel, N. (2021) ‘Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma’, BMC genomics, 22(1), p. 592. doi: 10.1186/s12864-021-07876-9.

Teufel, C., Horvath, E., Peter, A., Ercan, C., Piscuoglio, S., Hall, M. N., Finke, D. and Lehmann, F. M. (2021) ‘mTOR signaling mediates ILC3-driven immunopathology’, Mucosal Immunology, p. ahead of print. doi: 10.1038/s41385-021-00432-4.

Gao, R., Buechel, D., Kalathur, R. K. R., Morini, M. F., Coto-Llerena, M., Ercan, C., Piscuoglio, S., Chen, Q., Blumer, T., Wang, X., Dazert, E., Heim, M. H., Hall, M. N., Tang, F. and Christofori, G. (2021) ‘USP29-mediated HIF1α stabilization is associated with Sorafenib resistance of hepatocellular carcinoma cells by upregulating glycolysis’, Oncogenesis, 10(7), p. 52. doi: 10.1038/s41389-021-00338-7.

Muralidharan, S., Shimobayashi, M., Ji, S., Burla, B., Hall, M. N., Wenk, M. R. and Torta, F. (2021) ‘A reference map of sphingolipids in murine tissues’, Cell Reports, 35(11), p. 109250. doi: 10.1016/j.celrep.2021.109250.

Linder, M., Liko, D., Kancherla, V., Piscuoglio, S. and Hall, M. N. (2020) ‘Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells’. bioRxiv. doi: 10.1101/2020.10.11.334334. edoc | Open Access

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Berneiser, K., Shimobayashi, M., Stuttfeld, E., Hall, M. N., Ban, N. and Maier, T. (2020) ‘The 3.2Å resolution structure of human mTORC2’. bioRxiv. doi: 10.1101/2020.04.10.029835. edoc | Open Access

Shimobayashi, M., Shetty, S., Frei, I. C., Wölnerhanssen, B. K., Weissenberger, D., Dietz, N., Thomas, A., Ritz, D., Meyer-Gerspach, A. C., Maier, T., Hay, N., Peterli, R., Rohner, N. and Hall, M. N. (2020) ‘Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia’. bioRxiv. doi: 10.1101/2019.12.28.887794. edoc | Open Access

González, A., Hall, M. N., Lin, S.-C. and Hardie, D. G. (2020) ‘AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control’, Cell metabolism, 31(3), pp. 472–492. doi: 10.1016/j.cmet.2020.01.015. edoc | Open Access

Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Berneiser, K., Shimobayashi, M., Stuttfeld, E., Hall, M. N., Ban, N. and Maier, T. (2020) ‘The 3.2-Å resolution structure of human mTORC2’, Science advances, 6(45), p. eabc1251. doi: 10.1126/sciadv.abc1251. edoc | Open Access

Fu, W. and Hall, M. N. (2020) ‘Regulation of mTORC2 Signaling’, Genes, 11(9), p. 1045. doi: 10.3390/genes11091045. edoc | Open Access

Liko, D., Rzepiela, A., Vukojevic, V., Zavolan, M. and Hall, M. N. (2020) ‘Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs’, Proceedings of the National Academy of Sciences, 117(3), pp. 1524–1532. doi: 10.1073/pnas.1918931117. edoc | Open Access

Ding, X., Willenborg, S., Bloch, W., Wickström, S. A., Wagle, P., Brodesser, S., Roers, A., Jais, A., Brüning, J. C., Hall, M. N., Rüegg, M. A. and Eming, S. A. (2019) ‘Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation’, The Journal of Allergy & Clinical Immunology, 145(1), pp. 283–300.E8. doi: 10.1016/j.jaci.2019.07.033. edoc

Trinh, B., Hepprich, M., Betz, M. J., Burkard, T., Cavelti-Weder, C., Seelig, E., Meienberg, F., Kratschmar, D. V., Beuschlein, F., Reincke, M., Odermatt, A., Hall, M. N., Donath, M. Y. and Swierczynska, M. M. (2019) ‘Treatment of Primary Aldosteronism with mTORC1 Inhibitors’, The Journal of Clinical Endocrinology and Metabolism, 104(10), pp. 4703–4714. doi: 10.1210/jc.2019-00563. edoc | Open Access

Tang, F., Gao, R., Jeevan-Raj, B., Wyss, C. B., Kalathur, R. K. R., Piscuoglio, S., Ng, C. K. Y., Hindupur, S. K., Nuciforo, S., Dazert, E., Bock, T., Song, S., Buechel, D., Morini, M. F., Hergovich, A., Matthias, P., Lim, D.-S., Terracciano, L. M., Heim, M. H., Hall, M. N. and Christofori, G. (2019) ‘LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function’, Nature Communications, 10(1), p. 5755. doi: 10.1038/s41467-019-13591-7. edoc | Open Access

Benjamin, D. and Hall, M. N. (2019) ‘Lactate jump-starts mTORC1 in cancer cells’, EMBO Reports, 20(6), p. e48302. doi: 10.15252/embr.201948302. edoc | Open Access

Benjamin, D., Colombi, M., Moroni, C. and Hall, M. N. (2019) ‘mTOR dependent transformed human cells have a distinct set of essential genes from bcr-abl transformed cells’, bioRxiv, pp. 1–24. doi: 10.1101/737817. edoc | Open Access

Kessi-Pérez, E. I., Salinas, F., González, A., Su, Y., Guillamón, J. M., Hall, M. N., Larrondo, L. F. and Martínez, C. (2019) ‘KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae’, Frontiers in Microbiology, 10, p. 1686. doi: 10.3389/fmicb.2019.01686. edoc | Open Access

Li, J., Vázquez-García, I., Persson, K., González, A., Yue, J.-X., Barré, B., Hall, M. N., Long, A., Warringer, J., Mustonen, V. and Liti, G. (2019) ‘Shared molecular targets confer resistance over short and long evolutionary timescales’, Molecular biology and evolution, 36(4), pp. 691–708. doi: 10.1093/molbev/msz006. edoc

Suda, K., Kaneko, A., Shimobayashi, M., Nakashima, A., Tatsuya, M., Hall, M. N. and Ushimaru, T. (2019) ‘TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells’, Biochemical and Biophysical Research Communications, 511(2), pp. 434–439. doi: 10.1016/j.bbrc.2019.02.077. edoc | Open Access

Swierczynska, M. M., Betz, M. J., Colombi, M., Dazert, E., Jenö, P., Moes, S., Pfaff, C., Glatz, K., Reincke, M., Beuschlein, F., Donath, M. Y. and Hall, M. N. (2018) ‘Proteomic Landscape of Aldosterone-Producing Adenoma’, Hypertension (Dallas, Tex. : 1979), 73(2), pp. 469–480. doi: 10.1161/HYPERTENSIONAHA.118.11733. edoc

Benjamin, D., Robay, D., Hindupur, S. K., Pohlmann, J., Colombi, M., El-Shemerly, M. Y., Maira, S.-M., Moroni, C., Lane, H. A. and Hall, M. N. (2018) ‘Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells’, Cell Reports, 25(11), pp. 3047–3058.e4. doi: 10.1016/j.celrep.2018.11.043. edoc | Open Access

Mossmann, D., Park, S. and Hall, M. N. (2018) ‘mTOR signalling and cellular metabolism are mutual determinants in cancer’, Nature Reviews. Cancer, 18(12), pp. 744–757. doi: 10.1038/s41568-018-0074-8. edoc | Open Access

Martin, S. K., Fitter, S., El Khawanky, N., Grose, R. H., Walkley, C. R., Purton, L. E., Ruegg, M. A., Hall, M. N., Gronthos, S. and Zannettino, A. C. W. (2018) ‘mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis’, Scientific Reports, 8(1), p. 14501. doi: 10.1038/s41598-018-32858-5. edoc | Open Access

Kessi-Pérez, E. I., Salinas, F., Molinet, J., González, A., Muñiz, S., Guillamón, J. M., Hall, M. N., Larrondo, L. F. and Martínez, C. (2018) ‘Indirect monitoring of TORC1 signalling pathway reveals molecular diversity among different yeast strains’, Yeast, pp. 1–25. doi: 10.1002/yea.3351. edoc | Open Access

Mostofa, M. G., Rahman, M. A., Koike, N., Yeasmin, A. M., Islam, N., Waliullah, T. M., Hosoyamada, S., Shimobayashi, M., Kobayashi, T., Hall, M. N. and Ushimaru, T. (2018) ‘CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy’, Journal of Cell Biology, 217(8), p. 2675. doi: 10.1083/jcb.201706164. edoc | Open Access

Hindupur, S. K., Colombi, M., Fuhs, S. R., Matter, M. S., Guri, Y., Adam, K., Cornu, M., Piscuoglio, S., Ng, C. K. Y., Betz, C., Liko, D., Quagliata, L., Moes, S., Jenoe, P., Terracciano, L. M., Heim, M. H., Hunter, T. and Hall, M. N. (2018) ‘The protein histidine phosphatase LHPP is a tumour suppressor’, Nature, 555, pp. 678–682. doi: 10.1038/nature26140. edoc | Open Access

Dimitrakopoulos, C., Kumar Hindupur, S., Häfliger, L., Behr, J., Montazeri, H., Hall, M. N. and Beerenwinkel, N. (2018) ‘Network-based integration of multi-omics data for prioritizing cancer genes’, Bioinformatics , pp. 1–7. doi: 10.1093/bioinformatics/bty148. edoc | Open Access

Shimobayashi, M., Albert, V., Woelnerhanssen, B., Frei, I. C., Weissenberger, D., Meyer-Gerspach, A. C., Clement, N., Moes, S., Colombi, M., Meier, J. A., Swierczynska, M. M., Jenö, P., Beglinger, C., Peterli, R. and Hall, M. N. (2018) ‘Insulin resistance causes inflammation in adipose tissue’, Journal of Clinical Investigation, pp. 1–32. doi: 10.1172/JCI96139. edoc | Open Access

Bantug, G. R., Fischer, M., Grählert, J., Balmer, M. L., Unterstab, G., Develioglu, L., Steiner, R., Zhang, L., Costa, A. S. H., Gubser, P. M., Burgener, A.-V., Sauder, U., Löliger, J., Belle, R., Dimeloe, S., Lötscher, J., Jauch, A., Recher, M., Hönger, G., Hall, M. N., Romero, P., Frezza, C. and Hess, C. (2018) ‘Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells’, Immunity, 48(3), pp. 542–555. doi: 10.1016/j.immuni.2018.02.012. edoc

Singer, J., Ruscheweyh, H.-J., Hofmann, A. L., Thurnherr, T., Singer, F., Toussaint, N. C., Ng, C. K. Y., Piscuoglio, S., Beisel, C., Christofori, G., Dummer, R., Hall, M. N., Krek, W., Levesque, M., Manz, M. G., Moch, H., Papassotiropoulos, A., Stekhoven, D. J., Wild, P., Wüst, T., Rinn, B. and Beerenwinkel, N. (2018) ‘NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis’, Bioinformatics , 34(1), pp. 107–108. doi: 10.1093/bioinformatics/btx540. edoc | Open Access

Tang, F., Zhang, P., Ye, P., Lazarski, C. A., Wu, Q., Bergin, I. L., Bender, T. P., Hall, M. N., Cui, Y., Zhang, L., Jiang, T., Liu, Y. and Zheng, P. (2017) ‘A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice’, eLife, 6, p. e32497. doi: 10.7554/eLife.32497. edoc | Open Access

Hall, M. N. (2017) ‘An Amazing Turn of Events’, Cell, 171(1), pp. 18–22. doi: 10.1016/j.cell.2017.08.021. edoc

Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H. and Hall, M. N. (2017) ‘mTORC2 Promotes Tumorigenesis via Lipid Synthesis’, Cancer Cell, 32(6), pp. 807–832. doi: 10.1016/j.ccell.2017.11.011. edoc | Open Access

Bozadjieva, N., Blandino-Rosano, M., Chase, J., Dai, X.-Q., Cummings, K., Gimeno, J., Dean, D., Powers, A. C., Gittes, G. K., Rüegg, M. A., Hall, M. N., MacDonald, P. E. and Bernal-Mizrachi, E. (2017) ‘Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion’, The Journal of Clinical Investigation, 127(12), pp. 4379–4393. doi: 10.1172/JCI90004. edoc | Open Access

Benjamin, D. and Hall, M. N. (2017) ‘mTORC1 Controls Synthesis of Its Activator GTP’, Cell Reports , 19(13), pp. 2643–2644. doi: 10.1016/j.celrep.2017.06.032. edoc | Open Access

Blandino-Rosano, M., Barbaresso, R., Jimenez-Palomares, M., Bozadjieva, N., Werneck-de-Castro, J. P., Hatanaka, M., Mirmira, R. G., Sonenberg, N., Liu, M., Rüegg, M. A., Hall, M. N. and Bernal-Mizrachi, E. (2017) ‘Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing’, Nature Communications, 8, p. 16014. doi: 10.1038/ncomms16014. edoc | Open Access

González, A. and Hall, M. N. (2017) ‘Nutrient sensing and TOR signaling in yeast and mammals’, The EMBO Journal, 36(4), pp. 397–408. doi: 10.15252/embj.201696010. edoc

Fitter, S., Matthews, M. P., Martin, S. K., Xie, J., Ooi, S. S., Walkley, C. R., Codrington, J. D., Ruegg, M. A., Hall, M. N., Proud, C. G., Gronthos, S. and Zannettino, A. C. W. (2017) ‘mTORC1 Plays an Important Role in Skeletal Development by Controlling pre-Osteoblast Differentiation’, Molecular and Cellular Biology. American Society for Microbiology, pp. e00668–16. doi: 10.1128/MCB.00668-16. edoc

Swierczynska, M. M. and Hall, M. N. (2016) ‘eIF4A moonlights as an off switch for TORC1’, The EMBO Journal, 35(10), pp. 1013–1014. doi: 10.15252/embj.201694326. edoc

Grahammer, F., Nesterov, V., Ahmed, A., Steinhardt, F., Sandner, L., Arnold, F., Cordts, T., Negrea, S., Bertog, M., Ruegg, M. A., Hall, M. N., Walz, G., Korbmacher, C., Artunc, F. and Huber, T. B. (2016) ‘mTORC2 critically regulates renal potassium handling’, Journal of Clinical Investigation, 126(5), pp. 1773–1782. doi: 10.1172/JCI80304. edoc | Open Access

Drägert, K., Bhattacharya, I., Hall, M. N., Humar, R., Battegay, E. and Haas, E. (2016) ‘Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue’, Biochemical and Biophysical Research Communications, 473(1), pp. 317–322. doi: 10.1016/j.bbrc.2016.03.102. edoc

Zhang, L., Tschumi, B. O., Lopez-Mejia, I. C., Oberle, S. G., Meyer, M., Samson, G., Rüegg, M. A., Hall, M. N., Fajas, L., Zehn, D., Mach, J.-P., Donda, A. and Romero, P. (2016) ‘Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner’, Cell Reports , 14(5), pp. 1206–1217. doi: 10.1016/j.celrep.2015.12.095. edoc | Open Access

Dazert, E., Colombi, M., Boldanova, T., Moes, S., Adametz, D., Quagliata, L., Roth, V., Terracciano, L., Heim, M. H., Jenoe, P. and Hall, M. N. (2016) ‘Quantitative proteomics and phosphoproteomics on serial tumor biopsies from a sorafenib-treated HCC patient’, Proceedings of the National Academy of Sciences of the United States of America, 113(5), pp. 1381–1386. doi: 10.1073/pnas.1523434113. edoc

Hall, M. N. (2016) ‘TOR and paradigm change: cell growth is controlled’, Molecular Biology of the Cell, 27(18), pp. 2804–2806. doi: 10.1091/mbc.E15-05-0311. edoc

Ding, X., Bloch, W., Iden, S., Rüegg, M. A., Hall, M. N., Leptin, M., Partridge, L. and Eming, S. A. (2016) ‘mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation’, Nature Communications, 7, p. 13226. doi: 10.1038/ncomms13226. edoc | Open Access

Benjamin, D., Colombi, M., Hindupur, S. K., Betz, C., Lane, H. A., El-Shemerly, M. Y. M., Lu, M., Quagliata, L., Terracciano, L., Moes, S., Sharpe, T., Wodnar-Filipowicz, A., Moroni, C. and Hall, M. N. (2016) ‘Syrosingopine sensitizes cancer cells to killing by metformin’, Science Advances, 2(12), p. e1601756. doi: 10.1126/sciadv.1601756. edoc | Open Access

Herkert, B., Kauffmann, A., Mollé, S., Schnell, C., Ferrat, T., Voshol, H., Juengert, J., Erasimus, H., Marszalek, G., Kazic-Legueux, M., Billy, E., Ruddy, D., Stump, M., Guthy, D., Ristov, M., Calkins, K., Maira, S.-M., Sellers, W. R., Hofmann, F., Hall, M. N. and Brachmann, S. M. (2016) ‘Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition’, Cancer Research, 76(2), pp. 390–402. doi: 10.1158/0008-5472.CAN-14-3358. edoc

Driscoll, D. R., Karim, S. A., Sano, M., Gay, D. M., Jacob, W., Yu, J., Mizukami, Y., Gopinathan, A., Jodrell, D. I., Evans, T. R. J., Bardeesy, N., Hall, M. N., Quattrochi, B. J., Klimstra, D. S., Barry, S. T., Sansom, O. J., Lewis, B. C. and Morton, J. P. (2016) ‘mTORC2 signaling drives the development and progression of pancreatic cancer’, Cancer Research, 76(23), pp. 6911–6923. doi: 10.1158/0008-5472.CAN-16-0810. edoc

Swierczynska, M. M. and Hall, M. N. (2016) ‘mTOR in Metabolic and Endocrine Disorders’, in Maiese, K. (ed.) Molecules to Medicine with mTOR. Translating Critical Pathways into Novel Therapeutic Strategies. London: Academic Press, pp. 347–364. edoc

Fonseca, B. D., Graber, T. E., Hoang, H.-D., González, A., Soukas, A. A., Hernández, G., Alain, T., Swift, S. L., Weisman, R., Meyer, C., Robaglia, C., Avruch, J. and Hall, M. N. (2016) ‘Evolution of TOR and Translation Control’, in Hernández, G. and Jagus, R. (eds) Evolution of the Protein Synthesis Machinery and Its Regulation. Cham: Springer, pp. 327–412. doi: 10.1007/978-3-319-39468-8. edoc

Guri, Y. and Hall, M. N. (2016) ‘mTOR Signaling Confers Resistance to Targeted Cancer Drugs’, Trends in Cancer, 2(11), pp. 688–697. doi: 10.1016/j.trecan.2016.10.006. edoc

Albert, V., Svensson, K., Shimobayashi, M., Colombi, M., Muñoz, S., Jimenez, V., Handschin, C., Bosch, F. and Hall, M. N. (2016) ‘mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue’, EMBO Molecular Medicine, 8(3), pp. 232–246. doi: 10.15252/emmm.201505610. edoc | Open Access

Shimobayashi, M. and Hall, M. N. (2016) ‘Multiple amino acid sensing inputs to mTORC1’, Cell research, 26(1), pp. 7–20. doi: 10.1038/cr.2015.146. edoc

Shende, P., Xu, L., Morandi, C., Pentassuglia, L., Heim, P., Lebboukh, S., Berthonneche, C., Pedrazzini, T., Kaufmann, B. A., Hall, M. N., Rüegg, M. A. and Brink, M. (2016) ‘Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy’, Cardiovascular Research, 109(1), pp. 103–114. doi: 10.1093/cvr/cvv252. edoc | Open Access

Aimi, F., Georgiopoulou, S., Kalus, I., Lehner, F., Hegglin, A., Limani, P., Gomes de Lima, V., Rüegg, M. A., Hall, M. N., Lindenblatt, N., Haas, E., Battegay, E. J. and Humar, R. (2015) ‘Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult’, Scientific Reports, 5, p. 17705. doi: 10.1038/srep17705. edoc | Open Access

Liko, D. and Hall, M. N. (2015) ‘mTOR in health and in sickness’, Journal of Molecular Medicine, 93(10), pp. 1061–1073. doi: 10.1007/s00109-015-1326-7. edoc

Hindupur, S. K., González, A. and Hall, M. N. (2015) ‘The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control’, in Heald, R., Hariharan, I. K., and Wake, D. B. (eds) Size Control in Biology: From Organelles to Organisms. New York: Cold Spring Harbor Laboratory Press (Cold Spring Harbor perspectives in biology), pp. 221–240. edoc

Cornu, M., de Caudron de Coquereaumont, G. and Hall, M. N. (2015) ‘mTOR signaling in liver disease’, in Dufour, J.-F. and Clavien, P.-A. (eds) Signaling Pathways in Liver Diseases. West Sussex: John Wiley, pp. 314–325. doi: 10.1002/9781118663387.ch22. edoc

Albert, V. and Hall, M. N. (2015) ‘Reduced C/EBPβ-LIP translation improves metabolic health’, EMBO reports, Vol. 16, H. 8, pp. 881–882. doi: 10.15252/embr.201540757. edoc

Drägert, K., Bhattacharya, I., Pellegrini, G., Seebeck, P., Azzi, A., Brown, S. A., Georgiopoulou, S., Held, U., Blyszczuk, P., Arras, M., Humar, R., Hall, M. N., Battegay, E. and Haas, E. (2015) ‘Deletion of Rictor in Brain and Fat Alters Peripheral Clock Gene Expression and Increases Blood Pressure’, Hypertension, 66(2), pp. 332–339. doi: 10.1161/HYPERTENSIONAHA.115.05398. edoc

Hindupur, S. K., González, A. and Hall, M. N. (2015) ‘The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control’, Cold Spring Harbor Perspectives in Biology, 7(8), pp. 1–21. doi: 10.1101/cshperspect.a019141. edoc

Albert, V., Cornu, M. and Hall, M. N. (2015) ‘mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior’, Biochemical and Biophysical Research Communications, 464(2), pp. 480–486. doi: 10.1016/j.bbrc.2015.06.161. edoc

Ma, S., Venkatesh, A., Langellotto, F., Le, Y. Z., Hall, M. N., Rüegg, M. A. and Punzo, C. (2015) ‘Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival’, Experimental Eye Research, 135, pp. 1–13. doi: 10.1016/j.exer.2015.04.006. edoc | Open Access

Oliveira, A. P., Dimopoulos, S., Busetto, A. G., Christen, S., Dechant, R., Falter, L., Haghir, C. M., Jozefczuk, S., Ludwig, C., Rudroff, F., Schulz, J. C., González, A., Soulard, A., Stracka, D., Aebersold, R., Buhmann, J. M., Hall, M. N., Peter, M., Sauer, U. and Stelling, J. (2015) ‘Inferring causal metabolic signals that regulate the dynamic TORC1-dependent transcriptome’, Molecular systems biology, Vol. 11, H. 4, p. 802. doi: 10.15252/msb.20145475. edoc

Carr, T. D., Feehan, R. P., Hall, M. N., Rüegg, M. A. and Shantz, L. M. (2015) ‘Conditional disruption of rictor demonstrates a direct requirement for mTORC2 in skin tumor development and continued growth of established tumors’, Carcinogenesis, 36(4), pp. 487–497. doi: 10.1093/carcin/bgv012. edoc | Open Access

Venkatesh, A., Ma, S., Le, Y. Z., Hall, M. N., Rüegg, M. A. and Punzo, C. (2015) ‘Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice’, Journal of Clinical Investigation, 125(4), pp. 1446–1458. doi: 10.1172/JCI79766. edoc | Open Access

Martin, S. K., Fitter, S., Dutta, A. K., Matthews, M. P., Walkley, C. R., Hall, M. N., Ruegg, M. A., Gronthos, S. and Zannettino, A. C. W. (2015) ‘The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation’, Stem cells, Vol. 33, H. 4, pp. 1359–1365. doi: 10.1002/stem.1931. edoc

Lopez, R. J., Mosca, B., Treves, S., Maj, M., Bergamelli, L., Calderon, J. C., Bentzinger, C. F., Romanino, K., Hall, M. N., Rüegg, M. A., Delbono, O., Caputo, C. and Zorzato, F. (2015) ‘Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex’, Biochemical Journal, 466(1), pp. 123–135. doi: 10.1042/BJ20140935. edoc | Open Access

Faller, W. J., Jackson, T. J., Knight, J. R. P., Ridgway, R. A., Jamieson, T., Karim, S. A., Jones, C., Radulescu, S., Huels, D. J., Myant, K. B., Dudek, K. M., Casey, H. A., Scopelliti, A., Cordero, J. B., Vidal, M., Pende, M., Ryazanov, A. G., Sonenberg, N., Meyuhas, O., Hall, M. N., Bushell, M., Willis, A. E. and Sansom, O. J. (2015) ‘mTORC1-mediated translational elongation limits intestinal tumour initiation and growth’, Nature, 517(7535), pp. 497–500. doi: 10.1038/nature13896. edoc

González, A., Shimobayashi, M., Eisenberg, T., Merle, D. A., Pendl, T., Hall, M. N. and Moustafa, T. (2015) ‘TORC1 Promotes Phosphorylation of Ribosomal Protein S6 via the AGC Kinase Ypk3 in Saccharomyces cerevisiae’, PLoS ONE, Vol. 10, H. 3 , e0120250. doi: 10.1371/journal.pone.0120250. edoc

Albert, V. and Hall, M. N. (2014) ‘mTOR signaling in cellular and organismal energetics’, Current Opinion in Cell Biology. Elsevier, pp. 55–66. doi: 10.1016/j.ceb.2014.12.001. edoc

Stracka, D., Jozefczuk, S., Rudroff, F., Sauer, U. and Hall, M. N. (2014) ‘Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins’, Journal of Biological Chemistry, 289(36), pp. 25010–25020. doi: 10.1074/jbc.M114.574335. edoc | Open Access

Norrmén, C., Figlia, G., Lebrun-Julien, F., Pereira, J. A., Trötzmüller, M., Köfeler, H. C., Rantanen, V., Wessig, C., van Deijk, A. F., Smit, A. B., Verheijen, M. G., Rüegg, M. A., Hall, M. N. and Suter, U. (2014) ‘mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells’, Cell Reports , 9(2), pp. 646–660. doi: 10.1016/j.celrep.2014.09.001. edoc | Open Access

de Cabo, R., Carmona-Gutierrez, D., Bernier, M., Hall, M. N. and Madeo, F. (2014) ‘The Search for Antiaging Interventions : From Elixirs to Fasting Regimens’, Cell. Cell Press, pp. 1515–1526. doi: 10.1016/j.cell.2014.05.031. edoc

Cornu, M., Oppliger, W., Albert, V., Robitaille, A. M., Trapani, F., Quagliata, L., Fuhrer, T., Sauer, U., Terracciano, L. and Hall, M. N. (2014) ‘Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21’, Proceedings of the National Academy of Sciences of the United States of America, 111(32), pp. 11592–11599. doi: 10.1073/pnas.1412047111. edoc

Zhang, L., Tschumi, B. O., Corgnac, S., Rüegg, M. A., Hall, M. N., Mach, J.-P., Romero, P. and Donda, A. (2014) ‘Mammalian target of rapamycin complex 1 orchestrates invariant NKT cell differentiation and effector function’, Journal of Immunology, 193(4), pp. 1759–1765. doi: 10.4049/jimmunol.1400769. edoc

Grahammer, F., Haenisch, N., Steinhardt, F., Sander, L., Roerden, M., Arnold, F., Cordts, T., Wanner, N., Reichardt, W., Kerjaschki, D., Ruegg, M. A., Hall, M. N., Moulin, P., Busch, H., Boerries, M., Walz, G., Artunc, F. and Huber, T. B. (2014) ‘mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress’, Proceedings of the National Academy of Sciences of the United States of America, 111(27), pp. E2817-E2826. doi: 10.1073/pnas.1402352111. edoc | Open Access

Chou, P.-C., Oh, W. J., Wu, C.-C., Moloughney, J., Rüegg, M. A., Hall, M. N., Jacinto, E. and Werlen, G. (2014) ‘Mammalian target of rapamycin complex 2 modulates αβTCR processing and surface expression during thymocyte development’, Journal of Immunology, 193(3), pp. 1162–1170. doi: 10.4049/jimmunol.1303162. edoc | Open Access

Siamer, S., Guillas, I., Shimobayashi, M., Kunz, C., Hall, M. N. and Barny, M. A. (2014) ‘Expression of the bacterial type III effector DspA/E in Saccharomyces cerevisiae downregulates the sphingolipid biosynthetic pathway leading to growth-arrest’, Journal of Biological Chemistry, 289(26), pp. 18466–18477. doi: 10.1074/jbc.M114.562769. edoc | Open Access

Lebrun-Julien, F., Bachmann, L., Norrmén, C., Trötzmüller, M., Köfeler, H., Rüegg, M. A., Hall, M. N. and Suter, U. (2014) ‘Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination’, Journal of Neuroscience, 34(25), pp. 8432–8448. doi: 10.1523/JNEUROSCI.1105-14.2014. edoc | Open Access

Umemura, A., Park, E. J., Taniguchi, K., Lee, J. H., Shalapour, S., Valasek, M. A., Aghajan, M., Nakagawa, H., Seki, E., Hall, M. N. and Karin, M. (2014) ‘Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition’, Cell metabolism, Vol. 20, H. 1, pp. 133–144. doi: 10.1016/j.cmet.2014.05.001. edoc

Benjamin, D. and Hall, M. N. (2014) ‘mTORC1: Turning Off Is Just as Important as Turning On’, Cell, 156(4), pp. 627–628. doi: 10.1016/j.cell.2014.01.057. edoc

Chen, J., Tu, X., Esen, E., Joeng, K. S., Lin, C., Arbeit, J. M., Rüegg, M. A., Hall, M. N., Ma, L. and Long, F. (2014) ‘WNT7B promotes bone formation in part through mTORC1’, PLoS Genetics, 10(1), p. e1004145. doi: 10.1371/journal.pgen.1004145. edoc | Open Access

Shimobayashi, M. and Hall, M. N. (2014) ‘Making new contacts : the mTOR network in metabolism and signalling crosstalk’, Nature reviews. Molecular cell biology, Vol. 15, H. 3, pp. 155–162. doi: 10.1038/nrm3757. edoc

Wyder Peters, L., Molle, K. D., Thiemeyer, A., Knopf, A., Goxe, M., Guerry, P., Brodbeck, D., Colombi, M., Hall, M. N., Moroni, C. and Regenass, U. (2013) ‘An Isogenic Cell Panel Identifies Compounds That Inhibit Proliferation of mTOR-Pathway Addicted Cells by Different Mechanisms’, Journal of Biomolecular Screening, 19(1), pp. 131–144. doi: 10.1177/1087057113497798. edoc

Blazek, M., Betz, C., Reth, M., Hall, M. N., Zengerle, R. and Meier, M. (2013) ‘Proximity Ligation Assay for High Content Profiling of Cell Signaling Pathways on a Microfluidic Chip’, Molecular & cellular proteomics, Vol. 12, pp. 3898–3907. doi: 10.1074/mcp.M113.032821. edoc

Betz, C. and Hall, M. N. (2013) ‘Where is mTOR and what is it doing there?’, Journal of cell biology, Vol. 203, H. 4, pp. 563–574. doi: 10.1083/jcb.201306041. edoc | Open Access

Benjamin, D. and Hall, M. N. (2013) ‘TSC on the peroxisome controls mTORC1’, Nature Cell Biology, Vol. 15, H. 10, pp. 1135–1136. doi: 10.1038/ncb2849. edoc

Betz, C., Stracka, D., Prescianotto-Baschong, C., Frieden, M., Demaurex, N. and Hall, M. N. (2013) ‘mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology’, Proceedings of the National Academy of Sciences of the United States of America, 110(31), pp. 12526–12534. doi: 10.1073/pnas.1302455110. edoc

Hall, M. N. (2013) ‘On mTOR nomenclature’, Biochemical Society Transactions, 41(4), pp. 8817–8888. doi: 10.1042/BST20130092. edoc

Thedieck, K., Holzwarth, B., Prentzell, M. T., Boehlke, C., Kläsener, K., Ruf, S., Sonntag, A. G., Maerz, L., Grellscheid, S. N., Kremmer, E., Nitschke, R., Kuehn, E. W., Jonker, J. W., Groen, A. K., Reth, M., Hall, M. N. and Baumeister, R. (2013) ‘Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells’, Cell, 154(4), pp. 859–874. doi: 10.1016/j.cell.2013.07.031. edoc

Sauer, E., Imseng, S., Maier, T. and Hall, M. N. (2013) ‘Conserved sequence motifs and the structure of the mTOR kinase domain’, Biochemical Society Transactions, 41(4), pp. 889–895. doi: 10.1042/BST20130113. edoc

Bhattacharya, I., Drägert, K., Albert, V., Contassot, E., Damjanovic, M., Hagiwara, A., Zimmerli, L., Humar, R., Hall, M. N., Battegay, E. J. and Haas, E. (2013) ‘Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression’, Arteriosclerosis, thrombosis, and vascular biology, Vol. 33, H. 9, pp. 2105–2111. doi: 10.1161/ATVBAHA.112.301001. edoc

Shortt, J., Martin, B. P., Newbold, A., Hannan, K. M., Devlin, J. R., Baker, A. J., Ralli, R., Cullinane, C., Schmitt, C. A., Reimann, M., Hall, M. N., Wall, M., Hannan, R. D., Pearson, R. B., McArthur, G. A. and Johnstone, R. W. (2013) ‘Combined inhibition of PI3K-related DNA-damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas’, Blood, Vol. 121, H. 15, pp. 2964–2974. doi: 10.1182/blood-2012-08-446096. edoc

Saldivia, M., Barquilla, A., Bart, J. M., Diaz-González, R., Hall, M. N. and Navarro, M. (2013) ‘Target of rapamycin (TOR) kinase in Trypanosoma brucei : an extended family’, Biochemical Society Transactions, 41(4), pp. 934–938. doi: 10.1042/BST20130052. edoc

Robitaille, A. M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenö , P. and Hall, M. N. (2013) ‘Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis’, Science, 339(6125), pp. 1320–1323. doi: 10.1126/science.1228771. edoc

Shimobayashi, M., Oppliger, W., Moes, S., Jenö, P. and Hall, M. N. (2013) ‘TORC1-regulated protein kinase Npr1 phosphorylates Orm to stimulate complex sphingolipid synthesis’, Molecular Biology of the Cell, 24(6), pp. 870–881. doi: 10.1091/mbc.E12-10-0753. edoc | Open Access

Bentzinger, C. F., Lin, S., Romanino, K., Castets, P., Guridi, M., Summermatter, S., Handschin, C., Tintignac, L. A., Hall, M. N. and Rüegg, M. A. (2013) ‘Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy’, Skeletal muscle, Vol. 3, H. 1 , 6. doi: 10.1186/2044-5040-3-6. edoc | Open Access

Cornu, M., Albert, V. and Hall, M. N. (2013) ‘mTOR in aging, metabolism, and cancer’, Current Opinion in Genetics & Development, 23(1), pp. 53–62. doi: 10.1016/j.gde.2012.12.005. edoc

Durán, R. V. and Hall, M. N. (2012) ‘Glutaminolysis feeds mTORC1’, Cell Cycle, 11(22), pp. 4107–4108. doi: 10.4161/cc.22632. edoc | Open Access

Durán, R. V., Mackenzie, E. D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Bussolati, O., Rocha, S., Hall, M. N. and Gottlieb, E. (2012) ‘HIF-independent role of prolyl hydroxylases in the cellular response to amino acids’, Oncogene, 32(38), pp. 4549–4556. doi: 10.1038/onc.2012.465. edoc

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E. and Hall, M. N. (2012) ‘Glutaminolysis activates Rag-mTORC1 signaling’, Molecular Cell, 47(3), pp. 349–358. doi: 10.1016/j.molcel.2012.05.043. edoc

Liu, Q., Ren, T., Fresques, T., Oppliger, W., Niles, B. J., Hur, W., Sabatini, D. M., Hall, M. N., Powers, T. and Gray, N. S. (2012) ‘Selective ATP-competitive inhibitors of TOR suppress rapamycin-insensitive function of TORC2 in Saccharomyces cerevisiae’, ACS Chemical Biology, 7(6), pp. 982–987. doi: 10.1021/cb300058v. edoc

Durán, R. V. and Hall, M. N. (2012) ‘Regulation of TOR by small GTPases’, EMBO Reports, 13(2), pp. 121–128. doi: 10.1038/embor.2011.257. edoc

Cardon, C. M., Beck, T., Hall, M. N. and Rutter, J. (2012) ‘PAS kinase promotes cell survival and growth through activation of Rho1’, Science Signaling, 5(209), p. ra9. doi: 10.1126/scisignal.2002435. edoc

Robitaille, A. M. and Hall, M. N. (2012) ‘Ramping up mitosis : an AMPKα2-regulated signaling network promotes mitotic progression’, Molecular Cell, 45(1), pp. 8–9. doi: 10.1016/j.molcel.2011.12.018. edoc

Durán, R. V. and Hall, M. N. (2012) ‘Leucyl-tRNA synthetase : double duty in amino acid sensing’, Cell Research, 22(8), pp. 1207–1209. doi: 10.1038/cr.2012.68. edoc

Appenzeller-Herzog, C. and Hall, M. N. (2012) ‘Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling’, Trends in Cell Biology, 22(5), pp. 272–282. doi: 10.1016/j.tcb.2012.02.006. edoc | Open Access

Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A. and Hall, M. N. (2012) ‘Hepatic mTORC2 activates glycolysis and lipogenesis through akt, glucokinase, and SREBP1c’, Cell Metabolism, 15(5), pp. 725–738. doi: 10.1016/j.cmet.2012.03.015. edoc

Barquilla, A., Saldivia, M., Diaz, R., Bart, J. .-M., Vidal, I., Calvo, E., Hall, M. N. and Navarro, M. (2012) ‘Third target of rapamycin complex negatively regulates development of quiescence in Trypanosoma brucei’, Proceedings of the National Academy of Sciences of the United States of America, 109(36), pp. 14399–14404. doi: 10.1073/pnas.1210465109. edoc

Cybulski, N., Zinzalla, V. and Hall, M. N. (2012) ‘Inducible raptor and rictor Knockout Mouse Embryonic Fibroblasts’, Methods in Molecular Biology, 821, pp. 267–278. doi: 10.1007/978-1-61779-430-8_16. edoc

Benjamin, D., Colombi, M., Moroni, C. and Hall, M. N. (2011) ‘Rapamycin passes the torch: a new generation of mTOR inhibitors’, Nature Reviews. Drug Discovery, 10(11), pp. 868–880. doi: 10.1038/nrd3531. edoc

Hall, M. N. (2011) ‘The history and perspectives of TOR research’, Jikken Igaku (Experimental Medicine), Vol. 29, pp. 862–864. edoc

Loewith, R. and Hall, M. N. (2011) ‘Target of Rapamycin (TOR) in nutrient signaling and growth control’, Genetics, 189(4), pp. 1177–1201. doi: 10.1534/genetics.111.133363. edoc

Shende, P., Plaisance, I., Morandi, C., Pellieux, C., Berthonneche, C., Zorzato, F., Krishnan, J., Lerch, R., Hall, M. N., Ruegg, M. A., Pedrazzini, T. and Brink, M. (2011) ‘Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice’, Circulation, 123(10), pp. 1073–1082. doi: 10.1161/CIRCULATIONAHA.110.977066. edoc

Godel, M., Hartleben, B., Herbach, N., Liu, S., Zschiedrich, S., Lu, S., Debreczeni-Mor, A., Lindenmeyer, M. T., Rastaldi, M. .-P., Hartleben, G., Wiech, T., Fornoni, A., Nelson, R. G., Kretzler, M., Wanke, R., Pavenstadt, H., Kerjaschki, D., Cohen, C. D., Hall, M. N., Ruegg, M. A., Inoki, K., Walz, G. and Huber, T. B. (2011) ‘Role of mTOR in podocyte function and diabetic nephropathy in humans and mice’, Journal of Clinical Investigation, 121(6), pp. 2197–2209. doi: 10.1172/JCI44774. edoc | Open Access

Chan, J. C., Hannan, K. M., Riddell, K., Ng, P. Y., Peck, A., Lee, R. S., Hung, S., Astle, M. V., Bywater, M., Wall, M., Poortinga, G., Jastrzbeski, K., Sheppard, K. E., Hemmings, B. A., Hall, M. N., Johnstone, R. W., McArthur, G. A., Hannan, R. D. and Pearson, R. B. (2011) ‘AKT is a critical regulator of rRNA synthesis and cooperates with c-MYC to control ribosome biogenesis in cancer’, Science Signaling, 4(188), p. ra56. doi: 10.1126/scisignal.2001754. edoc

Dazert, E. and Hall, M. N. (2011) ‘mTOR signaling in disease’, Current Opinion in Cell Biology, 23(6), pp. 744–755. doi: 10.1016/j.ceb.2011.09.003. edoc

Hall, M. N. (2011) ‘Growth grows up COCB themed issue on cell division, growth, and death’, Current Opinion in Cell Biology, 23(6), pp. 705–706. doi: 10.1016/j.ceb.2011.09.008. edoc

Inoki, K., Mori, H., Wang, J., Suzuki, T., Hong, S., Yoshida, S., Blattner, S. M., Ikenoue, T., Ruegg, M. A., Hall, M. N., Kwiatkowski, D. J., Rastaldi, M. P., Huber, T. B., Kretzler, M., Holzman, L. B., Wiggins, R. C. and Guan, K. .-L. (2011) ‘mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice’, Journal of Clinical Investigation, 121(6), pp. 2181–2196. doi: 10.1172/JCI44771. edoc | Open Access

Zinzalla, V., Stracka, D., Oppliger, W. and Hall, M. N. (2011) ‘Activation of mTORC2 by Association with the Ribosome’, Cell, 144(5), pp. 757–768. doi: 10.1016/j.cell.2011.02.014. edoc

Colombi, M., Molle, K. D., Benjamin, D., Rattenbacher-Kiser, K., Schaefer, C., Betz, C., Thiemeyer, A., Regenass, U., Hall, M. N. and Moroni, C. (2011) ‘Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction’, Oncogene, 30(13), pp. 1551–1565. doi: 10.1038/onc.2010.539. edoc

Tamanoi, F. and Hall, M. N. (eds) (2010) Structure, Function and Regulation of TOR Complexes from Yeasts to Mammals. Amsterdam: Academic Press, Elsevier (The enzymes, Vol. 27-28). edoc

Zinzalla, V., Sturgill, T. W. and Hall (2010) ‘TOR complexes : composition, structure and phosphorylation’, in Structure, function and regulation of TOR complexes from yeasts to mammals. Amsterdam: Elsevier (The enzymes), pp. 1–20. edoc

Michels, A. A., Robitaille, A. M., Buczynski-Ruchonnet, D., Hodroj, W., Reina, J. H., Hall, M. N. and Hernandez, N. (2010) ‘mTORC1 directly phosphorylates and regulates human MAF1’, Molecular and cellular biology, Vol. 30, H. 15, pp. 3749–3757. doi: 10.1038/mp.a000094.01. edoc

Soulard, A., Cremonesi, A., Moes, S., Schutz, F., Jeno, P. and Hall, M. N. (2010) ‘The rapamycin-sensitive phosphoproteome reveals that TOR controls protein kinase A toward some but not all substrates’, Molecular Biology of the Cell, 21(19), pp. 3475–3486. doi: 10.1091/mbc.E10-03-0182. edoc | Open Access

Blagosklonny, M. V., Campisi, J., Sinclair, D. A., Bartke, A., Blasco, M. A., Bonner, W. M., Bohr, V. A., Brosh, R. M., Brunet, A., Depinho, R. A., Donehower, L. A., Finch, C. E., Finkel, T., Gorospe, M., Gudkov, A. V., Hall, M. N., Hekimi, S., Helfand, S. L., Karlseder, J., Kenyon, C., Kroemer, G., Longo, V., Nussenzweig, A., Osiewacz, H. D., Peeper, D. S., Rando, T. A., Rudolph, K. L., Sassone-Corsi, P., Serrano, M., Sharpless, N. E., Skulachev, V. P., Tilly, J. L., Tower, J., Verdin, E. and Vijg, J. (2010) ‘Impact papers on aging in 2009’, Aging, 2(3), pp. 111–121. doi: 10.18632/aging.100132. edoc | Open Access

Cornu, M. and Hall, M. N. (2010) ‘mTORC1 and mTORC2 in energy homeostasis’, in Structure, function and regulation of TOR complexes from yeasts to mammals. Amsterdam: Academic Press (The enzymes), pp. 263–278. edoc

Thedieck, K. and Hall, M. N. (2010) ‘Translational control by amino acids and energy’, in Handbook of cell signaling. San Diego, California: Elsevier Inc, pp. 2285–2293. edoc

Blagosklonny, M. V. and Hall, M. N. (2009) ‘Growth and aging : a common molecular mechanism’, Aging, Vol. 1, H. 4, pp. 357–362. edoc

Sturgill, T. W. and Hall, M. N. (2009) ‘Activating Mutations in TOR Are in Similar Structures As Oncogenic Mutations in PI3KCalpha’, ACS chemical biology, Vol. 4, no. 12, pp. 999–1015. edoc

Cybulski, N. and Hall, M. N. (2009) ‘TOR complex 2 : a signaling pathway of its own’, Trends in Biochemical Sciences, 34(12), pp. 620–627. doi: 10.1016/j.tibs.2009.09.004. edoc

Patursky-Polischuk, I., Stolovich-Rain, M., Hausner-Hanochi, M., Kasir, J., Cybulski, N., Avruch, J., Ruegg, M. A., Hall, M. N. and Meyuhas, O. (2009) ‘The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner’, Molecular and cellular biology, Vol. 29, H. 3, pp. 640–649. doi: 10.1128/MCB.00980-08. edoc | Open Access

Polak, P. and Hall, M. N. (2009) ‘mTOR and the control of whole body metabolism’, Current Opinion in Cell Biology, 21(2), pp. 209–218. doi: 10.1016/j.ceb.2009.01.02. edoc

Soulard, A., Cohen, A. and Hall, M. N. (2009) ‘TOR signaling in invertebrates’, Current Opinion in Cell Biology, 21(6), pp. 825–836. doi: 10.1016/j.ceb.2009.08.007. edoc

Cohen, A. and Hall, M. N. (2009) ‘An amino acid shuffle activates mTORC1’, Cell, 136(3), pp. 399–400. doi: 10.1016/j.cell.2009.01.021. edoc

Cybulski, N., Polak, P., Auwerx, J., Ruegg, M. A. and Hall, M. N. (2009) ‘mTOR complex 2 in adipose tissue negatively controls whole-body growth’, Proceedings of the National Academy of Sciences of the United States of America, 106(24), pp. 9902–9907. doi: 10.1073/pnas.0811321106. edoc | Open Access

Robitaille, A. M. and Hall, M. N. (2008) ‘mTor’, UCSD Nature Molecular Pages, 2008, A000094. doi: 10.1038/mp.a000094.01. edoc

Hall, M. N. (2008) ‘mTOR - what does it do?’, Transplantation proceedings, 40(10), pp. S5-S8. doi: 10.1016/j.transproceed.2008.10.009. edoc

Gander, S., Bonenfant, D., Altermatt, P., Martin, D. E., Hauri, S., Moes, S., Hall, M. N. and Jenoe, P. (2008) ‘Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase’, Rapid communications in mass spectrometry, Vol. 22, H. 23, pp. 3743–3753. doi: 10.1002/rcm.3790. edoc

Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M., Zorzato, F., Hall, M. N. and Ruegg, M. A. (2008) ‘Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy’, Cell Metabolism, 8(5), pp. 411–424. doi: 10.1016/j.cmet.2008.10.002. edoc

Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Ruegg, M. A. and Hall, M. N. (2008) ‘Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration’, Cell Metabolism, Vol. 8, H. 5, pp. 399–410. doi: 10.1016/j.cmet.2008.09.003. edoc

Sturgill, T. W., Cohen, A., Diefenbacher, M., Trautwein, M., Martin, D. E. and Hall, M. N. (2008) ‘TOR1 and TOR2 have distinct locations in live cells’, Eukaryotic Cell, Vol. 7, H. 10, pp. 1819–1830. edoc

Zinzalla, V. and Hall, M. N. (2008) ‘Signal transduction : linking nutrients to growth’, Nature, 454, pp. 287–288. doi: 10.1038/454287a. edoc

Jiang, H., Schiffer, E., Song, Z., Wang, J., Zurbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., Brecht, M., Jeno, P., Hall, M. N., Hager, K., Manns, M. P., Hecker, H., Ganser, A., Dohner, K., Bartke, A., Meissner, C., Mischak, H., Ju, Z. and Rudolph, K. L. (2008) ‘Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease’, Proceedings of the National Academy of Sciences of the United States of America, 105(32), pp. 11299–11304. doi: 10.1073/pnas.0801457105. edoc

Li, W., Petrimpol, M., Molle, K. D., Hall, M. N., Battegay, E. J. and Humar, R. (2007) ‘Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2’, Circulation Research, 100(1), pp. 79–87. doi: 10.1161/01.RES.0000253094.03023.3f. edoc

Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jeno, P., Arrieumerlou, C. and Hall, M. N. (2007) ‘PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis’, PLoS ONE, Vol. 2, H. 11 , e1217. doi: 10.1371/journal.pone.0001217. edoc

Sturgill, T. W. and Hall, M. N. (2007) ‘Holding back TOR advances mitosis’, Nature Cell Biology, Vol. 9, H. 11, pp. 1221–1222. edoc

Urban, J., Soulard, A., Huber, A., Lippman, S., Mukhopadhyay, D., Deloche, O., Wanke, V., Anrather, D., Ammerer, G., Riezman, H., Broach, J. R., De Virgilio, C., Hall, M. N. and Loewith, R. (2007) ‘Sch9 is a major target of TORC1 in Saccharomyces cerevisiae’, Molecular cell, Vol. 26, H. 5, pp. 663–674. edoc

Soulard, A. and Hall, M. N. (2007) ‘SnapShot : mTOR signaling’, Cell, 129(2), p. 434. doi: 10.1016/j.cell.2007.04.010. edoc

Linder, P., Shore, D. and Hall, M. N. (eds) (2006) Landmark papers in yeast biology. New York: Cold Spring Harbor Laboratory Press. edoc

Martin, D. E., Powers, T. and Hall, M. N. (2006) ‘Regulation of ribosome biogenesis : where is TOR?’, Cell Metabolism, Vol. 4, H. 4, pp. 259–260. edoc

Honma, Y., Kitamura, A., Shioda, R., Maruyama, H., Ozaki, K., Oda, Y., Mini, T., Jenö, P., Maki, Y., Yonezawa, K., Hurt, E., Ueno, M., Uritani, M., Hall, M. N. and Ushimaru, T. (2006) ‘TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients’, The EMBO Journal, 25(16), pp. 3832–3842. doi: 10.1038/sj.emboj.7601262. edoc

Wahl, P. R., Serra, A. L., Le Hir, M., Molle, K. D., Hall, M. N. and Wüthrich, R. P. (2006) ‘Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)’, Nephrology, Dialysis, Transplantation, 21(3), pp. 598–604. doi: 10.1093/ndt/gfi181. edoc | Open Access

Wullschleger, S., Loewith, R. and Hall, M. N. (2006) ‘TOR signaling in growth and metabolism’, Cell, 124(3), pp. 471–484. doi: 10.1016/j.cell.2006.01.016. edoc

Polak, P. and Hall, M. N. (2006) ‘mTORC2 Caught in a SINful Akt’, Developmental cell, Vol. 11, H. 4, pp. 433–434. edoc

Mulet, J. M., Martin, D. E., Loewith, R. and Hall, M. N. (2006) ‘Mutual antagonism of target of rapamycin and calcineurin signaling’, Journal of Biological Chemistry, 281(44), pp. 33000–33007. doi: 10.1074/jbc.M604244200. edoc | Open Access

Martin, D. E. and Hall, M. N. (2005) ‘The expanding TOR signaling network’, Current Opinion in Cell Biology, 17(2), pp. 158–166. doi: 10.1016/j.ceb.2005.02.008. edoc

Dames, S. A., Mulet, J. M., Rathgeb-Szabo, K., Hall, M. N. and Grzesiek, S. (2005) ‘The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability’, Journal of Biological Chemistry, 280(21), pp. 20558–20564. doi: 10.1074/jbc.M501116200. edoc | Open Access

Wullschleger, S., Loewith, R., Oppliger, W. and Hall, M. N. (2005) ‘Molecular organization of target of rapamycin complex 2’, Journal of Biological Chemistry, 280(35), pp. 30697–30704. doi: 10.1074/jbc.M505553200. edoc | Open Access

Kamada, Y., Fujioka, Y., Suzuki, N. N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M. N. and Ohsumi, Y. (2005) ‘Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization’, Molecular and Cellular Biology, Vol. 25, H. 16, pp. 7239–7248. edoc

Lorberg, A. and Hall, M. N. (2004) ‘TOR - the first 10 years’, Current Topics in Microbiology and Immunology, 279, pp. 1–18. doi: 10.1007/978-3-642-18930-2_1. edoc

Thomas, G., Sabatini, D. M. and Hall, M. N. (eds) (2004) TOR : target of rapamycin. Heidelberg: Springer Verlag GmbH (Current topics in microbiology and immunology, 279). doi: 10.1007/978-3-642-18930-2. edoc

Hall, M. N., Raff, M. and Thomas, G. (eds) (2004) Cell growth : control of cell size. New York: Cold Spring Harbor Laboratory Press (Cold Spring Harbor monograph series, 42). edoc

Loewith, R. and Hall, M. N. (2004) ‘TOR signaling in yeast : temporal and spatial control of cell growth’, in Cell growth. New York: Cold Spring Harbor Laboratory Press (Cold Spring Harbor monograph series), pp. 139–166. edoc

Schmelzle, T., Crespo, J. L. and Hall, M. N. (2004) ‘Translational control by amino acids and energy’, in Handbook of cell signaling. San Diego, California: Academic Press, pp. 299–303. edoc

Crespo, J. L., Helliwell, S. B., Wiederkehr, C., Demougin, P., Fowler, B., Primig, M. and Hall, M. N. (2004) ‘NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae’, Journal of Biological Chemistry, 279(36), pp. 37512–37517. doi: 10.1074/jbc.M407372200. edoc | Open Access

Audhya, A., Loewith, R., Parsons, A. B., Gao, L., Tabuchi, M., Zhou, H., Boone, C., Hall, M. N. and Emr, S. D. (2004) ‘Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton’, The EMBO Journal, 23(19), pp. 3747–3757. doi: 10.1038/sj.emboj.7600384. edoc

Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Ruegg, M. A., Hall, A. and Hall, M. N. (2004) ‘Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive’, Nature Cell Biology, Vol. 6, H. 11, pp. 1122–1128. doi: 10.1038/ncb1183. edoc

Morales-Johansson, H., Jenoe, P., Cooke, F. T. and Hall, M. N. (2004) ‘Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the INP51-associated proteins TAX4 and IRS4’, Journal of Biological Chemistry, 279(38), pp. 39604–39610. doi: 10.1074/jbc.M405589200. edoc | Open Access

Schmelzle, T., Beck, T., Martin, D. E. and Hall, M. N. (2004) ‘Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast’, Molecular and cellular biology, Vol. 24, H. 1, pp. 338–351. edoc

Martin, D. E., Demougin, P., Hall, M. N. and Bellis, M. (2004) ‘Rank difference analysis of microarrays (RDAM), a novel approach to statistical analysis of microarray expression profiling data’, BMC bioinformatics, Vol. 5 , 148. doi: 10.1186/1471-2105-5-148. edoc

Burri, L., Vascotto, K., Fredersdorf, S., Tiedt, R., Hall, M. N. and Lithgow, T. (2004) ‘Zim17 : a novel zinc finger protein essential for protein import into mitochondria’, Journal of Biological Chemistry, 279(48), pp. 50243–50249. doi: 10.1074/jbc.M409194200. edoc | Open Access

Martin, D. E., Soulard, A. and Hall, M. N. (2004) ‘TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1’, Cell, 119(7), pp. 969–979. doi: 10.1016/j.cell.2004.11.047. edoc

Bonenfant, D., Schmelzle, T., Jacinto, E., Crespo, J. L., Mini, T., Hall, M. N. and Jenoe, P. (2003) ‘Quantitation of changes in protein phosphorylation : a simple method based on stable isotope labeling and mass spectrometry’, Proceedings of the National Academy of Sciences of the United States of America, 100(3), pp. 880–885. doi: 10.1073/pnas.232735599. edoc

Jacinto, E. and Hall, M. N. (2003) ‘Tor signalling in bugs, brain and brawn’, Nature reviews. Molecular cell biology, Vol. 4, H. 2, pp. 117–126. edoc

Schmidt, A., Schmelzle, T. and Hall, M. N. (2002) ‘The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae’, Molecular Microbiology, 45(5), pp. 1433–1441. doi: 10.1046/j.1365-2958.2002.03110.x. edoc

Crespo, J. L., Powers, T., Fowler, B. and Hall, M. N. (2002) ‘The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine’, Proceedings of the National Academy of Sciences of the United States of America, 99(10), pp. 6784–6789. doi: 10.1073/pnas.102687599. edoc

Schmelzle, T., Helliwell, S. B. and Hall, M. N. (2002) ‘Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast’, Molecular and Cellular Biology, Vol. 22, H. 5, pp. 1329–1339. edoc

Crespo, J. L. and Hall, M. N. (2002) ‘Elucidating TOR signaling and rapamycin action : lessons from Saccharomyces cerevisiae’, Microbiology and molecular biology reviews, Vol. 66, H. 4, pp. 579–591. edoc

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P. and Hall, M. N. (2002) ‘Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control’, Molecular cell, Vol. 10, H. 3, pp. 457–468. edoc

Desrivieres, S., Cooke, F. T., Morales-Johansson, H., Parker, P. J. and Hall, M. N. (2002) ‘Calmodulin controls organization of the actin cytoskeleton via regulation of phosphatidylinositol (4,5)-bisphosphate synthesis in Saccharomyces cerevisiae’, Biochemical Journal, 366(3), pp. 945–951. doi: 10.1042/bj20020429. edoc

Beck, T., Delley, P. A. and Hall, M. N. (2001) ‘Control of the actin cytoskeleton by extracellular signals’, in Molecular interactions of actin. Heidelberg: Springer Verlag, pp. 231–262. edoc

Hall, M. N. and Sabatini, D. M. (2001) ‘TOR and Control of Cell Growth’, in Cahiers de la Fondation des Treilles, 13. Paris: [Centre d’études du bassin méditerranéen], pp. 62–82. edoc

Crespo, J. L., Daicho, K., Ushimaru, T. and Hall, M. N. (2001) ‘The GATA transcription factors GLN3 and GAT1 link TOR to salt stress in Saccharomyces cerevisiae’, Journal of Biological Chemistry, 276(37), pp. 34441–34444. doi: 10.1074/jbc.M103601200. edoc | Open Access

Jacinto, E., Guo, B., Arndt, K. T., Schmelzle, T. and Hall, M. N. (2001) ‘TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway’, Molecular cell, Vol. 8, H. 5, pp. 1017–1026. edoc

Friant, S., Lombardi, R., Schmelzle, T., Hall, M. N. and Riezman, H. (2001) ‘Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast’, The EMBO Journal, 20(23), pp. 6783–6792. doi: 10.1093/emboj/20.23.6783. edoc

Kunz, J., Schneider, U., Howald, I., Schmidt, A. and Hall, M. N. (2000) ‘HEAT repeats mediate plasma membrane localization of Tor2p in yeast’, Journal of Biological Chemistry, 275(47), pp. 37011–37020. doi: 10.1074/jbc.M007296200. edoc | Open Access

Cosentino, G. P., Schmelzle, T., Haghighat, A., Helliwell, S. B., Hall, M. N. and Sonenberg, N. (2000) ‘Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae’, Molecular and Cellular Biology, Vol. 20, H. 13, pp. 4604–4613. edoc

Kunz, J., Loeschmann, A., Deuter-Reinhard, M. and Hall, M. N. (2000) ‘FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast’, Molecular Microbiology, 37(6), pp. 1480–1493. doi: 10.1046/j.1365-2958.2000.02105.x. edoc

Schmelzle, T. and Hall, M. N. (2000) ‘TOR, a central controller of cell growth’, Cell, 103(2), pp. 253–262. doi: 10.1016/S0092-8674(00)00117-3. edoc

Brachat, A., Liebundguth, N., Rebischung, C., Lemire, S., Scharer, F., Hoepfner, D., Demchyshyn, V., Howald, I., Dusterhoft, A., Mostl, D., Pohlmann, R., Kotter, P., Hall, M. N., Wach, A. and Philippsen, P. (2000) ‘Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames’, Yeast, 16(3), pp. 241–253. doi: 10.1002/(SICI)1097-0061(200002)16:3<241::AID-YEA517>3.0.CO;2-T. edoc

Danaie, P., Altmann, M., Hall, M. N., Trachsel, H. and Helliwell, S. B. (1999) ‘CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E’, Biochemical Journal, 340(1), pp. 135–141. doi: 10.1042/bj3400135. edoc

Inagaki, M., Schmelzle, T., Yamaguchi, K., Irie, K., Hall, M. N. and Matsumoto, K. (1999) ‘PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast’, Molecular and Cellular Biology, Vol. 19, H. 12, pp. 8344–8352. edoc

Beck, T. and Hall, M. N. (1999) ‘The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors’, Nature, 402, pp. 689–692. doi: 10.1038/45287. edoc

Delley, P. A. and Hall, M. N. (1999) ‘Cell wall stress depolarizes cell growth via hyperactivation of RHO1’, The Journal of cell biology, Vol. 147, H. 1, pp. 163–174. doi: 10.1083/jcb.147.1.163. edoc | Open Access

Beck, T., Schmidt, A. and Hall, M. N. (1999) ‘Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast’, The Journal of cell biology, Vol. 146, H. 6, pp. 1227–1238. doi: 10.1083/jcb.146.6.1227. edoc | Open Access

Helliwell, S. B., Howald, I., Barbet, N. and Hall, M. N. (1998) ‘TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae’, Genetics, 148(1), pp. 99–112. edoc

Bickle, M., Delley, P. A., Schmidt, A. and Hall, M. N. (1998) ‘Cell wall integrity modulates RHO1 activity via the exchange factor ROM2’, The EMBO Journal, 17(8), pp. 2235–2245. doi: 10.1093/emboj/17.8.2235. edoc

Schmidt, A. and Hall, M. N. (1998) ‘Signaling to the actin cytoskeleton’, Annual review of cell and developmental biology, Vol. 14, pp. 305–338. edoc

Schmidt, A., Beck, T., Koller, A., Kunz, J. and Hall, M. N. (1998) ‘The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease’, The EMBO Journal, 17(23), pp. 6924–6931. doi: 10.1093/emboj/17.23.6924. edoc

Desrivieres, S., Cooke, F. T., Parker, P. J. and Hall, M. N. (1998) ‘MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae’, Journal of Biological Chemistry, 273(25), pp. 15787–15793. doi: 10.1074/jbc.273.25.15787. edoc | Open Access

Helliwell, S. B., Schmidt, A., Ohya, Y. and Hall, M. N. (1998) ‘The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton’, Current Biology, 8(22), pp. 1211–1214. doi: 10.1016/S0960-9822(07)00511-8. edoc

Cooke, F. T., Dove, S. K., McEwen, R. K., Painter, G., Holmes, A. B., Hall, M. N., Michell, R. H. and Parker, P. J. (1998) ‘The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae’, Current Biology, 8(22), pp. 1219–1222. doi: 10.1016/S0960-9822(07)00513-1. edoc

Thomas, G. and Hall, M. N. (1997) ‘TOR signalling and control of cell growth’, Current Opinion in Cell Biology, 9(6), pp. 782–787. doi: 10.1016/S0955-0674(97)80078-6. edoc

Schmidt, A., Bickle, M., Beck, T. and Hall, M. N. (1997) ‘The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2’, Cell, 88(4), pp. 531–542. doi: 10.1016/S0092-8674(00)81893-0. edoc

Koller, A., Heitman, J. and Hall, M. N. (1996) ‘Regional bivalent-univalent pairing versus trivalent pairing of a trisomic chromosome in Saccharomyces cerevisiae’, Genetics, 144(3), pp. 957–966. edoc

Hall, M. N. (1996) ‘Yeast cloning book cloning’, Trends in Cell Biology, 6(2), p. 80. doi: 10.1016/0962-8924(96)81023-3. edoc

Beretta, L., Gingras, A. C., Svitkin, Y. V., Hall, M. N. and Sonenberg, N. (1996) ‘Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation’, The EMBO Journal, 15(3), pp. 658–664. vailable at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC449984/pdf/emboj00003-0216.pdf. edoc

Hall, M. N. (1996) ‘The TOR signalling pathway and growth control in yeast’, Biochemical Society Transactions, 24(1), pp. 234–239. doi: 10.1042/bst0240234. edoc

Schmidt, A., Kunz, J. and Hall, M. N. (1996) ‘TOR2 is required for organization of the actin cytoskeleton in yeast’, Proceedings of the National Academy of Sciences of the United States of America, 93(24), pp. 13780–13785. edoc

Barbet, N. C., Schneider, U., Helliwell, S. B., Stansfield, I., Tuite, M. F. and Hall, M. N. (1996) ‘TOR controls translation initiation and early G1 progression in yeast’, Molecular Biology of the Cell, 7(1), pp. 25–42. doi: 10.1091/mbc.7.1.25. edoc | Open Access

Hall, M. N. (1996) ‘Drug discovery : rational serendipity’, Trends in Biochemical Sciences, 21(8), pp. 322–323. doi: 10.1016/S0968-0004(96)80142-3. edoc

Hall, M. N. (1994) ‘Cytosplasm-to-nucleus signaling in yeast: use of immunosuppressive drugs as probes’, in Trafic des Protéines chez les Microorganismes. Paris: C.N.R.S. France, pp. 55–57. edoc

Helliwell, S. B., Wagner, P., Kunz, J., Deuter-Reinhard, M., Henriquez, R. and Hall, M. N. (1994) ‘TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast’, Molecular Biology of the Cell, 5(1), pp. 105–118. doi: 10.1091/mbc.5.1.105. edoc | Open Access

Hottiger, T., De Virgilio, C., Hall, M. N., Boller, T. and Wiemken, A. (1994) ‘The role of trehalose synthesis for the acquisition of thermotolerance in yeast : II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro’, European Journal of Biochemistry, 219(1-2), pp. 187–193. doi: 10.1111/j.1432-1033.1994.tb19929.x. edoc

Schmidt, A., Hall, M. N. and Koller, A. (1994) ‘Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake’, Molecular and Cellular Biology, Vol. 14, H. 10, pp. 6597–6606. edoc

Garcia-Bustos, J. F., Marini, F., Stevenson, I., Frei, C. and Hall, M. N. (1994) ‘PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus’, The EMBO Journal, 13(10), pp. 2352–2361. vailable at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC395100/pdf/emboj00058-0116.pdf. edoc

Hall, M. N., Linder, P. and Hall, M. N. (eds) (1993) The early days of yeast genetics. New York: Cold Spring Harbor Laboratory Press. edoc

Heitman, J., Koller, A., Cardenas, M. E. and Hall, M. N. (1993) ‘Identification of immunosuppressive drug targets in yeast’, Methods, Vol. 5, no. 2, pp. 176–187. edoc

Kunz, J. and Hall, M. N. (1993) ‘Cyclosporin A, FK506 and rapamycin : more than just immunosuppression’, Trends in Biochemical Sciences, 18(9), pp. 334–348. doi: 10.1016/0968-0004(93)90069-Y. edoc

Wagner, P. and Hall, M. N. (1993) ‘Nuclear protein transport is functionally conserved between yeast and higher eukaryotes’, FEBS Letters, 321(2-3), pp. 261–266. doi: 10.1016/0014-5793(93)80121-A. edoc

Heitman, J., Koller, A., Kunz, J., Henriquez, R., Schmidt, A., Movva, N. R. and Hall, M. N. (1993) ‘The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae’, Molecular and cellular biology, Vol. 13, H. 8, pp. 5010–5019. edoc

Kunz, J., Henriquez, R., Schneider, U., Deuter-Reinhard, M., Movva, N. R. and Hall, M. N. (1993) ‘Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression’, Cell, 73(3), pp. 585–596. doi: 10.1016/0092-8674(93)90144-F. edoc

Heitman, J., Movva, N. R. and Hall, M. N. (1992) ‘Proline isomerases at the crossroads of protein folding, signal transduction, and immunosuppression’, The New Biologist, Vol. 4, no. 5, pp. 448–460. edoc

Tinland, B., Koukolíková-Nicola, Z., Hall, M. N. and Hohn, B. (1992) ‘The T-DNA-linked VirD2 protein contains two distinct functional nuclear localization signals’, Proceedings of the National Academy of Sciences of the United States of America, 89(16), pp. 7442–7446. doi: 10.1073/pnas.89.16.7442. edoc

Davis, E. S., Becker, A., Heitman, J., Hall, M. N. and Brennan, M. B. (1992) ‘A yeast cyclophilin gene essential for lactate metabolism at high temperature’, Proceedings of the National Academy of Sciences of the United States of America, 89(23), pp. 11169–11173. edoc

Tinland, B., Hall, M. N. and Hohn, B. (1991) ‘Mechanism of T-DNA transfer’, in Proceedings of the 5th International Symposium on the molecular genetics of plant-microbe interactions, Interlaken, Switzerland, September 9-14, 1990. Dordrecht: Kluwer Academic Publ. (Advances in molecular genetics of plant-microbe interactions), pp. 79–84. edoc

Heitman, J., Movva, N. R. and Hall, M. N. (1991) ‘Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast’, Science, 253(5022), pp. 905–909. doi: 10.1126/science.1715094. edoc

Heitman, J., Movva, N. R., Hiestand, P. C. and Hall, M. N. (1991) ‘FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae’, Proceedings of the National Academy of Sciences of the United States of America, 88(5), pp. 1948–1952. edoc

Garcia-Bustos, J. F., Wagner, P. and Hall, M. N. (1991) ‘Nuclear import substrates compete for a limited number of binding sites : evidence for different classes of yeast nuclear import receptors’, Journal of Biological Chemistry, 266(33), pp. 22303–22306. edoc | Open Access

Garcia-Bustos, J. F., Wagner, P. and Hall, M. N. (1991) ‘Yeast cell-free nuclear protein import requires ATP hydrolysis’, Experimental Cell Research, 192(1), pp. 213–219. doi: 10.1016/0014-4827(91)90178-W. edoc

Garcia-Bustos, J., Heitman, J. and Hall, M. N. (1991) ‘Nuclear protein localization’, Biochimica et Biophysica Acta, 1071(1), pp. 83–101. doi: 10.1016/0304-4157(91)90013-M. edoc

Hall, M. N., Craik, C. and Hiraoka, Y. (1990) ‘Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal’, Proceedings of the National Academy of Sciences of the United States of America, 87(18), pp. 6954–6958. doi: 10.1073/pnas.87.18.6954. edoc

Wagner, P., Kunz, J., Koller, A. and Hall, M. N. (1990) ‘Active transport of proteins into the nucleus’, FEBS Letters, 275(1-2), pp. 1–5. doi: 10.1016/0014-5793(90)81425-N. edoc

Hall, M. N. and Fried, S. R. (1988) ‘Is nuclear protein localization receptor-mediated?’, in Molecular Biology of Intracellular Protein Sorting and Organelle Assembly. New York: Alan R. Liss, pp. 187–192. edoc

Silver, P. A. and Hall, M. N. (1988) ‘Transport of proteins into the nucleus’, in Protein transfer and organelle biogenesis. San Diego, Calif.: Academic Press, pp. 749–769. edoc

Hall, M. N. and Johnson, A. D. (1987) ‘Homeo domain of the yeast repressor alpha 2 is a sequence-specific DNA-binding domain but is not sufficient for repression’, Science, 237(4818), pp. 1007–1012. doi: 10.1126/science.2887035. edoc

Benson, S. A., Hall, M. N. and Rasmussen, B. A. (1987) ‘Signal sequence mutations that alter coupling of secretion and translation of an Escherichia coli outer membrane protein’, Journal of bacteriology, Vol. 169, H. 10, pp. 4686–4691. edoc

Garcia-Bustos, J., Heitman, J. and Hall, M. N. (1986) ‘Nuclear protein localization signals in yeast’, in Yeast cell biology (UCLA-Symposia on molecular and cellular biology, N.S. Vol. 33). Alan R. Liss, Inc.: New York, pp. 421–425. edoc

Hall, M. N. (1986) ‘Considerations on the mechanism of nuclear protein localization in yeast’, in Nucleocytoplasmic transport. Heidelberg: Springer Verlag, pp. 247–252. edoc

Silhavy, T. J., Benson, S. A. and Hall, M. N. (1985) ‘A mechanism to couple transport and export’, in Microbiology - 1985. Washington: American Society for Microbiology, pp. 454–458. edoc

Benson, S. A., Hall, M. N. and Silhavy, T. J. (1985) ‘Genetic analysis of protein export in Escherichia coli K12’, Annual Review of Biochemistry, 54, pp. 101–134. doi: 10.1146/annurev.bi.54.070185.000533. edoc

Hall, M. N. (1985) ‘Studies on the mechanism of nuclear protein localization in yeast’, in Protein transport and secretion. New York: Cold Spring Harbor Laboratory Press (Current communications in molecular biology), pp. 196–200. edoc

Berman, M. L., Jackson, D. E., Fowler, A., Zabin, I., Christensen, L., Fiil, N. P. and Hall, M. N. (1984) ‘Gene fusion techniques: Cloning vectors for manipulating IacZ gene fusions’, Gene Analysis Techniques, 1(3), pp. 43–51. doi: 10.1016/0735-0651(84)90016-5. edoc

Hall, M. N., Hereford, L. and Herskowitz, I. (1984) ‘Targeting of E. coli beta-galactosidase to the nucleus in yeast’, Cell, 36(4), pp. 1057–1065. doi: 10.1016/0092-8674(84)90055-2. edoc

Hall, M. N., Gabay, J. and Schwartz, M. (1983) ‘Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli’, The EMBO Journal, 2(1), pp. 15–19. vailable at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555079/pdf/emboj00254-0017.pdf. edoc

Taylor, R. K., Hall, M. N. and Silhavy, T. J. (1983) ‘Isolation and characterization of mutations altering expression of the major outer membrane porin proteins using the local anaesthetic procaine’, Journal of Molecular Biology, 166(3), pp. 273–282. doi: 10.1016/S0022-2836(83)80085-0. edoc

Hall, M. N., Gabay, J., Debarbouille, M. and Schwartz, M. (1982) ‘A role for mRNA secondary structure in the control of translation initiation’, Nature, 295, pp. 616–618. doi: 10.1038/295616a0. edoc

Hall, M. N. and Schwartz, M. (1982) ‘Reconsidering the early steps of protein secretion’, Annales de Microbiologie, 133a(1), pp. 123–127. edoc

Benson, S., Emr, S., Hall, M., Silhavy, T. and Sodergren, E. (1982) ‘Genetic approaches to study export of LamB to the outer membrane’, Annales de Microbiologie, Vol. 133a, H. 1, pp. 115–122. edoc

Hall, M. N., Schwartz, M. and Silhavy, T. J. (1982) ‘Sequence information within the lamB genes in required for proper routing of the bacteriophage lambda receptor protein to the outer membrane of Escherichia coli K-12’, Journal of Molecular Biology, 156(1), pp. 93–112. doi: 10.1016/0022-2836(82)90461-2. edoc

Hall, M. N., Emr, S. D. and Silhavy, T. J. (1981) ‘Genetic studies on mechanisms of protein localization in Escherichia coli K-12’, in Membrane transport and neuroreceptors. New York: Alan R. Liss, pp. 81–97. edoc

Taylor, R. K., Hall, M. N., Enquist, L. and Silhavy, T. J. (1981) ‘Identification of OmpR : a positive regulatory protein controlling expression of the major outer membrane matrix porin proteins of Escherichia coli K-12’, Journal of bacteriology, Vol. 147, H. 1, pp. 255–258. edoc

Hall, M. N. and Silhavy, T. J. (1981) ‘Genetic analysis of the ompB locus in Escherichia coli K-12’, Journal of Molecular Biology, 151(1), pp. 1–15. doi: 10.1016/0022-2836(81)90218-7. edoc

Hall, M. N. and Silhavy, T. J. (1981) ‘Genetic analysis of the major outer membrane proteins of Escherichia coli’, Annual Review of Genetics, 15, pp. 91–142. doi: 10.1146/annurev.ge.15.120181.000515. edoc

Hall, M. N. and Silhavy, T. J. (1981) ‘The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12’, Journal of Molecular Biology, 146(1), pp. 23–43. doi: 10.1016/0022-2836(81)90364-8. edoc

Hall, M. N., Emr, S. D. and Silhavy, T. J. (1980) ‘Genetic studies on mechanisms of protein localization in Escherichia coli K-12’, Journal of Supramolecular Structure, 13(2), pp. 147–163. doi: 10.1002/jss.400130203. edoc

Emr, S. D., Hall, M. N. and Silhavy, T. J. (1980) ‘A mechanism of protein localization : the signal hypothesis and bacteria’, The Journal of cell biology, Vol. 86, H. 3, pp. 701–711. doi: 10.1083/jcb.86.3.701. edoc | Open Access

Moreno, F., Fowler, A. V., Hall, M., Silhavy, T. J., Zabin, I. and Schwartz, M. (1980) ‘A signal sequence is not sufficient to lead beta-galactosidase out of the cytoplasm’, Nature, Vol. 286, pp. 356–359. edoc

Hall, M. N. and Silhavy, T. J. (1979) ‘Transcriptional regulation of Escherichia coli K-12 major outer membrane protein 1b’, Journal of bacteriology, Vol. 140, H. 2, pp. 342–350. edoc

迈克尔·霍尔在细胞信号传导和癌症代谢方面的重要贡献而闻名，最著名的是 mTOR 的发现和研究。mTOR 是一种蛋白激酶，是细胞和生物体生长的重要调节因子，在癌症、糖尿病以及衰老过程中发挥关键作用。