颉伟，男，1981年出生，博士，清华大学生命科学学院研究员。1999-2003年，北京大学生命科学学院，获学士学位；2003-2008年，美国加州大学洛杉矶分校，获博士学位；2006-2008年，美国加州大学洛杉矶分校，获硕士学位；2008-2009年，美国加州大学洛杉矶分校博士后；2009-2013年，美国圣地亚哥Ludwig肿瘤研究所，加州大学圣地亚哥分校博士后；2013年起，任清华大学生命科学学院研究员。

颉伟，男，1981年出生，博士，清华大学生命科学学院研究员。

1999-2003年，北京大学生命科学学院 生物科学 学士

2003-2008年，美国加州大学洛杉矶分校 分子生物学 博士

2006-2008年，美国加州大学洛杉矶分校 统计学 硕士

2008-2009年，美国加州大学洛杉矶分校 博士后

2009-2013年，美国圣地亚哥Ludwig肿瘤研究所，加州大学圣地亚哥分校 博士后

2013年-， 清华大学生命科学学院 助理教授、副教授、教授

中国动物学会副理事长

2019年9月20日，获得“科学探索奖”-生命科学。

2022年12月，获得2021年度北京市科学技术奖—杰出青年中关村奖。

2023年1月，“新基石研究员项目”

研究兴趣包括表观遗传学，基因组学和发育生物学。同时利用分子生物学、发育生物学和计算生物学的方法，采用干湿实验结合的方式，研究干细胞分化和个体发育以及人类疾病中的表观遗传调控机制。本实验室将致力于：（1）动物胚胎早期发育过程中的表观遗传调控；（2）干细胞分化过程中的表观遗传调控；（3）调控序列如启动子、增强子、绝缘子以及三维基因组在发育和细胞命运决定过程中的功能；（4）表观遗传相关人类疾病的调控机理。

1. Shuyan Ji,* Fengling Chen,* Paula Stein,* Jiacheng Wang,* Ziming Zhou,* Lijuan Wang,* Qing Zhao, Zili Lin, Bofeng Liu, Kai Xu, Fangnong Lai, Zhuqing Xiong, Xiaoyu Hu, Tianxiang Kong, Feng Kong, Bo Huang, Qiujun Wang, Qianhua Xu, Qiang Fan, Ling Liu, Carmen J. Williams, Richard M. Schultz,# and Wei Xie#. OBOX regulates mouse zygotic genome activation and early development. Nature (2023).

2. Zhuoning Zou,* Chuanxin Zhang,* Qiuyan Wang,* Zhenzhen Hou,* Zhuqing Xiong, Feng Kong, Qiujun Wang, Jinzhu Song, Boyang Liu, Bofeng Liu, Lijuan Wang, Fangnong Lai, Qiang Fan, Wenrong Tao, Shuai Zhao, Xiaonan Ma, Miao Li, Keliang Wu, Han Zhao,# Zijiang Chen,# and Wei Xie#. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science 2022 Sep 8:eabo7923 (2022).

3. Zhuqing Xiong,* Kai Xu,* Zili Lin,* Feng Kong,* Qiujun Wang,* Yujun Quan, Qian-qian Sha, Fajin Li, Zhuoning Zou, Ling Liu, Shuyan Ji, Yuling Chen, Hongmei Zhang, Jianhuo Fang, Guang Yu, Bofeng Liu, Lijuan Wang, Huili Wang, Haiteng Deng, Xuerui Yang, Heng-yu Fan, Lei Li,# and Wei Xie #. Ultrasensitive Ribo-seq reveals translational landscapes during mammalian oocyte-to-embryo transition and pre-implantation development. Nat Cell Biol 24, 968–980 (2022).

4. Xukun Lu,* Yu Zhang,* Lijuan Wang,* Leyun Wang,* Huili Wang, Qianhua Xu, Yunlong Xiang, Chaolei Chen, Feng Kong, Weikun Xia, Zili Lin, Sinan Ma, Ling Liu, Xiangguo Wang, Hemin Ni, Wei Li, # Yong Guo,# Wei Xie#. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances. 2021;7(48):eabi6178 (2021).

5. Bofeng Liu,* Qianhua Xu,* Qiujun Wang,* Su Feng,* Fangnong Lai, Peizhe Wang, Fangyuan Zheng, Yunlong Xiang, Jingyi Wu, Junwei Nie, Cui Qiu, Weikun Xia, Lijia Li, Guang Yu, Zili Lin, Kai Xu, Zhuqing Xiong, Feng Kong, Ling Liu, Chunyi Huang, Yang Yu, Jie Na, Wei Xie# (2020). The landscape of RNA Pol II binding reveals a step-wise transition during ZGA. Nature (1-6)

6. Qiujun Wang,* Guang Yu,* Xuan Ming,* Weikun Xia, Xiguang Xu, Yu Zhang, Wenhao Zhang, Yuanyuan Li, Chunyi Huang, Hehuang Xie, Bing Zhu, # Wei Xie# (2020). Imprecise DNMT1 activity coupled with neighbor-guided correction enables robust yet flexible epigenetic inheritance. Nature Genetics 52 (828-839).

7. Ke Zhang,* Dan-Ya Wu,* Hui Zheng,* Yao Wang,* Qiao-Ran Sun, Xin Liu, Li-Yan Wang, Wen-Jing Xiong, Qiujun Wang, James D. P. Rhodes, Kai Xu, Lijia Li, Zili Lin, Guang Yu, Weikun Xia, Bo Huang, Zhenhai Du, Yao Yao, Kim A. Nasmyth, Robert J. Klose, Yi-Liang Miao, #Wei Xie# (2020). Analysis of genome architecture during SCNT reveals a role of cohesin in impeding minor ZGA. Molecular Cell 79 (234-250).

8. Yunlong Xiang,* Yu Zhang,* Qianhua Xu, Chen Zhou, Bofeng Liu, Zhenhai Du, Ke Zhang, Bingjie Zhang, Xiaoxiao Wang, Srimonta Gayen, Ling Liu, Yao Wang, Yuanyuan Li, Qiujun Wang, Sundeep Kalantry, Lei Li & Wei Xie # (2019) Epigenomic analysis of gastrulation identifies a unique chromatin state for primed pluripotency. Nature Genetics 52 (95-105).

9. Zhenhai Du,* Hui Zheng,* Yumiko K.Kawamura,* KeZhang,* Johanna Gassler, Sean Powell, Qianhua Xu, Zili Lin, Kai Xu, QianZhou, Evgeniy A.Ozonov, Nathalie Véron, Bo Huang, Lijia Li, Guang Yu, Ling Liu, Wan Kin Au Yeung, Peizhe Wang, Lei Chang, Qiujun Wang, Aibin He, Yujie Sun, Jie Na, Qingyuan Sun, Hiroyuki Sasaki, Kikuë Tachibana, Antoine H.F.M.Peters,# Wei Xie # (2019) Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Molecular Cell 77(825-839).

10. Weikun Xia,* Jiawei Xu,* ,# Guang Yu,* Guidong Yao,* Kai Xu, Xueshan Ma, Nan Zhang, Bofeng Liu, Tong Li, Zili Lin, Xia Chen, Lijia Li, Qiujun Wang, Dayuan Shi, Senlin Shi, Yile Zhang, Wenyan Song, Haixia Jin Linli Hu, Zhiqin Bu, Yang Wang, Jie Na, Wei Xie # , Ying-Pu Sun # (2019) Resetting histone modifications during human parental-to-zygotic transition. Science 365 (353-360).

11. Qianhua Xu,* Yunlong Xiang,* Qiujun Wang,* Leyun Wang,* Julie Brind’Amour, Aaron Blair Bogutz, Yu Zhang, Bingjie Zhang, Guang Yu, Weikun Xia, Zhenhai Du, Chunyi Huang, Jing Ma, Hui Zheng, Yuanyuan Li, Chao Liu, Cheryl Lyn Walker, Eric Jonasch, Louis Lefebvre, Min Wu, Matthew Lorincz, Wei Li # , Li Li # , Wei Xie # (2019) SETD2 regulates the maternal epigenome and embryonic development. Nature Genetics 51 (844–856).

12. Jingyi Wu,* Jiawei Xu,* Bofeng Liu,* Guidong Yao,* Peizhe Wang,* Zili Lin,* Bo Huang, Xuepeng Wang, Tong Li, Senlin Shi, Nan Zhang, Fuyu Duan, Jia Ming, Xiangyang Zhang, Wenbin Niu, Wenyan Song, Haixia Jin, Yihong Guo, Shanjun Dai, Linli Hu, Lanlan Fang, Qiujun Wang, Yuanyuan Li, Wei Li, Jie Na #, Wei Xie # # (2018) Chromatin analysis in human early development reveals epigenetic transition during ZGA. Nature 557 (256–260).

13. Zhenhai Du, Hui Zheng, Bo Huang, Rui Ma, Jingyi Wu, Xianglin Zhang, Jing He, Yunlong Xiang, Qiujun Wang, Yuanyuan Li, Jing Ma, Xu Zhang, Ke Zhang, Michael Q. Zhang, Juntao Gao, Jesse R. Dixon, Xiaowo Wang, Jianyang Zeng, Wei Xie # (2017) Allelic reprogramming of 3D chromatin architecture during early mammalian development. Nature 547 (232-235).

14. Bingjie Zhang,* Hui Zheng,* Bo Huang,* Wenzhi Li,* Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Zai Chang, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na # , Wei Xie # (2016). Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature 537 (553-557).

15. Jingyi Wu,* Bo Huang,* He Chen, Qiangzong Yin, Yang Liu, Yunlong Xiang, Bingjie Zhang, Bofeng Liu, Qiujun Wang, Weikun Xia, Wenzhi Li, Yuanyuan Li, Jing Ma, Xu Peng, Hui Zheng, Jia Ming, Wenhao Zhang, Jing Zhang, Geng Tian, Feng Xu, Zai Chang, Jie Na, Xuerui Yang, Wei Xie # (2016). The landscape of accessible chromatin in mammalian preimplantation embryos. Nature 534 (652-657).