夏灵,男,1965年10月出生,浙江
缙云人。1980年至1982年就读于
缙云盘溪中学,1987年毕业于
浙江大学电机系工业自动化专业,获工学学士学位,1996年毕业于
浙江大学生物医学工程系,获
生物医学工程专业博士学位,毕业后留校任教,任浙江大学生物医学工程系教授、博士生导师,
浙江大学生物医学工程研究所副所长。
研究项目
1、
国家自然科学基金面上项目,61671405,超高场MRI射频场生物效应与快速成像技术研究,2017/01-2020/12,65万,在研,主持。
2、国家重大科研仪器研制项目,61527811,用于心肌缺血/猝死早期检测的心电动力学图新型装置,2016/01-2020/12,89万,在研,参加。
3、国家自然科学基金面上项目,81171421,考虑心房详细解剖结构的房颤建模仿真及其应用研究,2012/01-2015/12,58万元,已结题,主持。
4、国家973计划项目子课题,2010CB732502,MRI部分K-空间数据成像与射频技术,2010/01-2014/12,214万元,已结题,参加(浙江大学课题负责人)。
5、国家十二五科技支撑计划项目子课题,2011BAI12B01,超导磁共振成像系统的研发—MRI脉冲序列设计,2012/01-2014/12,120万元,已结题,参加。
6、国家自然科学基金青年基金项目,30900332,永磁MRI涡流屏蔽问题及梯度场非线性失真校正研究,2010/01-2012/12,20万元,已结题,参加。
7、浙江省新世纪151人才(二层次),2010年,
生物医学工程。
8、国家973计划项目子课题,2007CB512100,恶性
室性心律失常的模拟和早期干预,2008/01-2012/12,40万元,已结题,参加(浙江大学课题负责人)。
9、
国家863计划项目,2006AA02Z307,虚拟心脏模型及其关键生物计算技术研究、2006/12-2008/12,80万元,已结题,主持。
10、
国家自然科学基金面上项目,3057048,基于离子通道的心力衰竭建模仿真及其应用研究,2006/01-2008/12,26万元,已结题,主持。
11、教育部新世纪优秀人才支持计划项目,NCET-04-0550,磁共振成像系统关键技术研究,2005/01-2007/12,50万元,已结题,主持。
12、国家973计划项目子课题,2003CB716106,电生理信号的三维逆问题求解与信息融合,2004/01-2008/12,140万元,已结题,参加(浙江大学课题负责人)。
13、国家自然科学基金面上项目,30370400,全人体电磁模型及其在电磁场生物效应中的应用研究,2004/01-2006/12,20万元,已结题,主持。
14、国家自然科学基金面上项目,30170243,考虑心脏力学特性的心电仿真及其逆问题研究,2002/01-2004/12,17万元,已结题,主持。
15、首届全国优秀博士学位论文奖获得者,1999年,
生物医学工程。
16、国家自然科学基金青年基金项目,39700032,WPW综合征房室旁道无创性定位新技术的研究,1998/01-2000/12,12万元,已结题,主持。
研究与成果
虚拟心脏建模仿真
虚拟心脏建模仿真属于国际Physiome Project(生理组计划)中的Cardiome子计划,力求从分子、基因、蛋白、离子通道、亚细胞器、单个心肌细胞、心肌组织以及整个心脏器官等多尺度对心脏进行建模仿真,研究心脏的生理病理机制和心脏疾病的诊疗方法。
生物医学建模与仿真实验室率先在国内开展虚拟心脏建模仿真研究工作,经过二十多年的努力,构建了一个基于离子通道层次的具有详细解剖结构的多尺度虚拟心脏模型,并对正常心脏电生理、力学特性,以及
心肌缺血、
心力衰竭、多种心律失常等心脏疾病进行仿真研究,此外还对心电逆问题、CRT心力衰竭优化治疗、房颤导管射频消融优化治疗等心脏病诊疗方法进行研究,取得了一系列的创新研究成果,是国际上计算心脏领域最活跃的研究组之一。主要成果有:
(1)构建了一个离子通道水平的高空间时间分辨率的Cardiome-CN虚拟心脏模型,该虚拟心脏模型是国际上解剖结构划分最详细的心脏模型;(2)开创性构建了电生理—力学复合心脏模型(Physics in Medicine and Biology 2005,被列为该期刊年度国际同行评价最高和被下载次数最多的论文之一),并提出了基于动态心脏模型体表心电图仿真新方法(Methods of Information in Medicine 2006),使虚拟心脏模型研究工作从单纯的电生理或力学的片面角度上升到电力学耦合的更符合心脏生理实际的层次;(3)提出了动态心电逆问题的新概念及其求解方法(IEEE TBME 2009),首次将心脏的运动信息考虑进心电逆问题的求解过程,改变了三十多年来假设心脏是静止不动的存在较大系统误差的心电逆问题求解方法;(4)提出了一种基于完全截尾最小二乘(TTLS)的心电逆问题正则化新方法(IEEE TBME 2008,被作为该期的封面提示论文刊出),该方法能很好同时处理测量噪声和几何噪声,解决了国际心电逆问题研究领域困扰了三十多年的难题;(5)首次在三维虚拟心脏模型上对
Brugada综合征基因变异离子通道心脏疾病进行仿真研究(Physiological Measurement 2006),结果发现患者体温升高到39.5度时心肌动作电位发生突变,从而引起二相折返和室颤,这可能是患者发生猝死的原因之一,另外还证实了其病理部位在右心室流出道周围的推测,从而为今后发展定点给药法治疗Brugada综合征的新技术提供理论依据。(6)首次在三维虚拟心脏模型上对
束支传导阻滞引起的
充血性心力衰竭进行仿真研究(Physics in Medicine and Biology,2009;CMMM 2012),该研究对今后发展临床
心力衰竭的起搏器治疗优化方案具有重要的科学意义和实用价值。(7)建立了左右心房肌细胞的
动力学模型和详细解剖结构的虚拟心脏模型(Zhejiang Univ-Sci B,2010,2012;CMMM, 2012)。(8)仿真研究了rogue RyR对心室肌钙波的影响(Physics Biology,2010;CMMM 2012;JMCC 2013)。
磁共振成像系统关键技术
主要针对主磁体、梯度线圈、射频线圈等核心部件进行优化设计,研究磁体匀场技术,以及研究并行成像方法、相位解缠绕方法、激发脉冲序列设计等,从软硬件方面提高MRI图像的质量。主要成果有:
(1)永磁MRI系统涡流问题建模仿真方法(JMR 2012; CMR 2011);(2)提出了一种基于边界元法的梯度线圈设计方法(IEEE TM 2010),该法不但可以有效设计梯度线圈,而且可以很方便处理排线密集度的工程约束问题;(3)提出了一种基于
有限差分法的梯度线圈设计方法(IEEE TBME 2012),该法的优点是可以考虑将线圈设计融合到
磁共振系统的电磁场/生物组织的FDTD模型中去,从而方便计算分析高场MRI系统工作过程中产生的生物效应;(4)提出了基于磁场――谐波混合法的被动匀场新方法(IEEE TAS 2011);(5)提出了三维体选择性激发序列设计方法(IEEE TMI 2012)。
奖项荣誉
专利成果
发表论文
1. Liu Haipeng, Gong Yinglan, Leng Xinyi, Xia Ling, Wong Ka Sing, Ou Shanxing, Leung Thomas W., Wang Defeng, and Shi Lin, Estimating current and long-term risks of coronary artery in silico by fractional flow reserve, wall shear stress and low-density lipoprotein filtration rate[J]. Biomedical Physics and Engineering Express, 2018. 4(2).
2. Gao Yuan, Xia Ling, Gong Ying-Lan, and Zheng Ding-Chang, Electrocardiogram (ECG) patterns of left anterior fascicular block and conduction impairment in ventricular myocardium: a whole-heart model-based simulation study[J]. J Zhejiang Univ Sci B, 2018. 19(1):49-56.
3. Wen X., Guo Bokai, Gong Yinglan, Xia Ling, and Yu Jie, Cardiodynamicsgram: a novel tool for monitoring cardiac function in exercise training[J]. Journal of Sports Sciences, 2018(Journal Article):1-5.
4. Gao Yuan, Gong Yinglan, and Xia Ling, Simulation of Atrial Fibrosis Using Coupled Myocyte-Fibroblast Cellular and Human Atrial Models[J]. Computational and Mathematical Methods in Medicine, 2017. 2017(Journal Article).
5. Deng Muqing, Tang Min, Wang Cong, Shan Liang, Zhang Linfeng, Zhang Jingtao, Wu Weiming, and Xia Ling, Cardiodynamicsgram as a New Diagnostic Tool in Coronary Artery Disease Patients With Nondiagnostic Electrocardiograms[J]. American Journal of Cardiology, 2017. 119(5):698-704.
6. Zhifeng Chen(#),Ling Xia(*),Feng Liu,Qiuliang Wang,Yi Li,Xuchen Zhu,Feng Huang,An Improved Non-Cartesian Partially Parallel Imaging by Exploiting Artificial Sparsity,Magnetic Resonance in Medicine,2017, 271-279.
7. Ling Dai, Yunliang Zang, Dingchang Zheng, Ling Xia, and Yinglan Gong, Role of CaMKII and PKA in Early Afterdepolarization of Human Ventricular Myocardium Cell: A Computational Model Study[J]. Computational and Mathematical Methods in Medicine, 2016. 2016:1-8.
8. Kong, Xia,Zhu, Minhua,Xia, Ling(*),Wang, Qiuliang(*),Li, Yi,Zhu, Xuchen,Liu, Feng,Crozier, Stuart,Passive shimming of a superconducting magnet using the L-1-norm regularized least square algorithm,Journal of Magnetic Resonance,2016,263:122-125.
9. Jiaqi Liu Yinglan Gong, Ling Xia, and Xiaopeng Zhao, In Silico Investigation into Cellular Mechanisms of Cardiac Alternans in Myocardial Ischemia[J]. Computational and Mathematical Methods in Medicine, 2016. 2016:1-9.
10. Xia Kong(#),Minhua Zhu,Ling Xia(*),Stuart Crozier,Qiuliang Wang,Zhipeng Ni,Feng Liu,A novel passive shimming method for the correction of magnetic fields above the patient bed in MRI,Journal of Magnetic Resonance,2015,257:64-69.
11. Cheng, Yiyuan(#),He, Wei,Xia, Ling(*),Liu, Feng,Design of Shimming Rings for Small Permanent MRI Magnet Using Sensitivity-Analysis-Based Particle Swarm Optimization Algorithm,Journal of Medical and Biological Engineering,2015,35(4):448-454.
12. Yinglan Gong, Yuan Gao, Zhanghong Lu, Dingchang Zheng, Dongdong Deng , Ling Xia*, Preliminary Simulation Study of Atrial Fibrillation Treatment Procedure Based on A Detailed Human Atrial Model[J]. Journal of Clinical Trials in Cardiology, 2015. 2:1-9.
13. Jiang Mingfeng, Liu Yuan, Xu Wenlong, Hu Jie, Wang Yaming, Gong Yinglan, and Xia Ling, Efficient compressed sensing reconstruction using group sparse total variation regularization[J]. Journal of Medical Imaging and Health Informatics, 2015. 5(5):907-917.
14. Jiang Mingfeng, Zhang Heng, Zhu Lingyan, Cao Li, Wang Yaming, Xia Ling, and Gong Yinglan, Noninvasive reconstruction of cardiac transmembrane potentials using a kernelized extreme learning method[J]. Physics in Medicine and Biology, 2015. 60(8):3237-3253.
15. Zhan Heqing, Gong Yinglan, Lu Zhanghong, Xia Ling, and Kuijpers Nico H. L., Fibroblasts reduce tension and strain of cardiac fiber: A modeling study of cardiac electromechanics[J]. Experimental and Clinical Cardiology, 2014. 20(5):3180-3190.
16. He-Qing Zhan,Ling XIA., Guo-Fa Shou Yun-Liang Zang Feng LIU, Stuart Crozier, Fibroblast proliferation alters cardiac excitation conduction and contraction: a computational study[J]. Journal of Zhejiang University-Science B(Biomedicine & Biotechnology), 2014. 15(3):225-242.
17. Yun-Liang Zang Ling XIA., Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem[J]. Journal of Zhejiang University-Science B (Biomedicine& Biotechnology), 2014. 15(3):201-211.
18. He, Wei,Xia, Ling(*),Liu, Feng,Sparse-Representation-Based Direct Minimum L-p-Norm Algorithm for MRI Phase Unwrapping,Computational and Mathematical Methods in Medicine,2014,2014:1-11, Article ID 134058.
19. Zang Yunliang, Xia Ling, Chen-Izu Ye, and Izu Leighton, Transmural Gradient of Ito and INak Profoundly Influence Ventricular Action Potential Duration[J]. Biophysical Journal, 2014. 106(2):117a-117a.
20. Wei He(#),Ling Xia(*),Region-growing phase unwrapping method based on mask,Journal of Zhejiang University (Engineering Science),2014,(04):792-797.
21. Zhu, Minhua(#),Xia, Ling(*),Liu, Feng,Unconventional gradient coil designs in magnetic resonance imaging,Critical Reviews in Biomedical Engineering,2014,42(6):493-526.
22. Jiang, Ming-Feng(#)(*),Zhu, Li-Tao,Wang, Ya-Ming,Xia, Ling,Gong, Ying-Lan,Parallel MRI based on combination of nonlinear GRAPPA and SENSE,Journal of Zhejiang University(Engineering Science),2014,48(10):1865-1870.
23. Jin, Zhaoyang,Xia, Ling,Zhang, Minming,Du, Yiping P.(*),Background-Suppressed MR Venography of the Brain Using Magnitude Data: A High-Pass Filtering Approach,Computational and Mathematical Methods in Medicine,2014,2014:1-9, Article ID812785.
24. Yunliang Zang(#),Ling Xia,Ye Chen-Izu,Leighton Izu,Transmural Gradient of Ito and INak Profoundly Influence Ventricular Action Potential Duration,Biophysical Journal,2014,106(2, Supplement 1):117a~117a
25. Yunliang Zang,Ling Dai,Heqing Zhan,Jianhong Dou,Ling Xia(*),Henggui Zhang,Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: Especially the role of up-regulated CaMKII and SR Ca2+ leak,Journal of Molecular and Cellular Cardiology,2013,56(7):34~43
26. Zhan, Heqing,Xia, Ling(*),Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current: A Simulation Study,Computational and Mathematical Methods in Medicine,2013,2013, Article ID 238676
27. Mingfeng Jiang,Jin Jin,Feng Liu(*),Yeyang Yu,Ling Xia,Yaming Wang,Stuart Crozier,Sparsity-constrained SENSE reconstruction: An efficient implementation using a fast composite splitting algorithm,Magnetic Resonance Imaging,2013,31(7):1218~1227
28. Zhang Chen(#),Shou Guo-Fa,Lu Hong,Hua Ning,Tang Xue-Zheng,Xia Ling,Ma Ping(*),Tang Fa-Kuan,A new magneto-cardiogram study using a vector model with a virtual heart and the boundary element method,Chinese Physics B,2013,22(9)
29. Jiang, Mingfeng(*),Wang, Yaming,Xia, Ling,Liu, Feng,Jiang, Shanshan,Huang, Wenqing,The combination of self-organizing feature maps and support vector regression for solving the inverse ECG problem,Computers & Mathematics with Applications,2013,66(10):1981~1990
30. Dou, Jianhong,Xia, Ling(*),Deng, Dongdong,Zang, Yunliang,Shou, Guofa,Bustos, Cesar,Tu, Weifeng,Liu, Feng,Crozier, Stuart,A Study of Mechanical Optimization Strategy for Cardiac Resynchronization Therapy Based on an Electromechanical Model,Computational and Mathematical Methods in Medicine,2012,2012, Article ID 948781
31. Zhu, Minhua,Xia, Ling,Liu, Feng,Zhu, Jianfeng,Kang, Liyi,Crozier, Stuart,A Finite Difference Method for the Design of Gradient Coils in MRI-An Initial Framework,IEEE Transactions on Biomedical Engineering,2012,59(9):2412~2421
32. Lu, Luyao,Xia, Ling(*),Zhu, Xiuwei,Simulation of Arrhythmogenic Effect of Rogue RyRs in Failing Heart by Using a Coupled Model,Computational and Mathematical Methods in Medicine,2012,2012, Article ID 183978
33. Deng, Dongdong,Jiao, Peifeng,Ye, Xuesong,Xia, Ling(*),An Image-Based Model of the Whole Human Heart with Detailed Anatomical Structure and Fiber Orientation,Computational and Mathematical Methods in Medicine,2012,2012, Article ID 891070
34. Shao, Tingting,Xia, Ling(*),Tao, Guisheng,Chi, Jieru,Liu, Feng,Crozier, Stuart,Advanced Three-Dimensional Tailored RF Pulse Design in Volume Selective Parallel Excitation,IEEE Transactions on Medical Imaging,2012,31(5):997~1007
35. Deng, Dong-dong,Gong, Ying-lan,Shou, Guo-fa,Jiao, Pei-feng,Zhang, Heng-gui,Ye, Xue-song,Xia, Ling(*),Simulation of biatrial conduction via different pathways during sinus rhythm with a detailed human atrial model,Journal of Zhejiang University-Science B(Biomedicine & Biotechnology),2012,13(9):676~694
36. He, Wei,Cheng, Yiyuan,Xia, Ling(*),Liu, Feng,A New Particle Swarm Optimization-Based Method for Phase Unwrapping of MRI Data,Computational and Mathematical Methods in Medicine,2012,2012, Article ID 475745
37. Xia, Ling(*),Murray, Alan,Zheng, Dingchang,Liu, Feng,Ye, Xuesong,Ning, Gangmin,Cardiovascular System Modeling,Computational and Mathematical Methods in Medicine,2012,2012, Article ID 583172
38. Ying Nan,Tian Jian,Yu SaiNan,Zhou Jing,Ling ShuCai,Xia Ling,Ye XueSong(*),Progress in defining heterogeneity and modeling periglomerular cells in the olfactory bulb,Science China Life Sciences,2012,55(7):567~575
39. Shou, Guofa,Xia, Ling(*),Jiang, Mingfeng,Dou, Jianhong,Magnetocardiography Simulation Based on an Electrodynamic Heart Model,IEEE Transactions on Magnetics,2011,47(9):2224~2230
40. Li, Xia,Xia, Ling(*),Chen, Wufan,Liu, Feng,Crozier, Stuart,Xie, Dexin,Finite element analysis of gradient z-coil induced eddy currents in a permanent MRI magnet,Journal of Magnetic Resonance,2011,208(1):148~155
41. Li, Xia,Xia, Ling(*),Liu, Feng,Crozier, Stuart,Xie, Dexin,Characterization and Reduction of X-Gradient Induced Eddy Currents in a NdFeB Magnetic Resonance Imaging Magnet-3D Finite Element Method-Based Numerical Studies,Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering,2011,39B(1):47~58
42. Shou, Guofa,Xia, Ling(*),Liu, Feng,Jiang, Mingfeng,Crozier, Stuart,On epicardial potential reconstruction using regularization schemes with the L1-norm data term,Physics in Medicine and Biology,2011,56(1):57~72
43. Shou Guo-Fa(*),Xia Ling,Ma Ping,Tang Fa-Kuan,Dai Ling,Simulation study of a magnetocardiogram based on a virtual heart model: effect of a cardiac equivalent source and a volume conductor,Chinese Physics B,2011,20(3):1~10
44. Jiang, Mingfeng(*),Zhu, Lingyan,Wang, Yaming,Xia, Ling,Shou, Guofa,Liu, Feng,Crozier, Stuart,Application of kernel principal component analysis and support vector regression for reconstruction of cardiac transmembrane potentials,Physics in Medicine and Biology,2011,56(6):1727~1742
45. Ye, Xuesong(*),Zeng, Yong,Zhou, Tao,Liu, Feng,Liu, Jun,Sha, Jian,Xu, Xiaoyuan,Xia, Ling,In Situ Comparative Studies of Self-Assembly Adsorption of Bovine Serum Albumin on Nano Films by Atomic Force Microscopy,Journal of Nanoscience and Nanotechnology,2011,11(12):10765~10769
46. Jin, Zhaoyang,Xia, Ling,Lou, Min,Zhang, Minming,Du, Yiping P.(*),MR Venography of the Brain With Enhanced Vessel Contrast Using Image-Domain High-Pass Filtering of the Susceptibility Phase Shift,Journal of Magnetic Resonance Imaging,2011,34(5):1218~1225
47. Liu, Feng(*),Zhu, Jianfeng,Xia, Ling,Crozier, Stuart,A Hybrid Field-Harmonics Approach for Passive Shimming Design in MRI,IEEE Transactions on Applied Superconductivity,2011,21(2):60~67
48. Chi, Jieru,Liu, Feng(*),Xia, Ling,Shao, Tingting,Crozier, Stuart,An Improved Cylindrical FDTD Algorithm and Its Application to Field-Tissue Interaction Study in MRI,IEEE Transactions on Magnetics,2011,47(2):466~470
49. Zhu, Xiuwei,Zhou, Xiaobo(*),Lewis, Michael T.,Xia, Ling,Wong, Stephen,Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study,Journal of Theoretical Biology,2011,269(1):138~149
50. Xia, Ling,Gong, Ying-lan,Zhu, Xiu-wei,Zhang, Yu,Sun, Qi,Zhang, Heng-gui,Mathematical models of canine right and left atria cardiomyocytes,Journal of Zhejiang University-Science B(Biomedicine & Biotechnology),2010,11(6):402~416
51. Shou, Guofa,Xia, Ling,Liu, Feng,Zhu, Minhua,Li, Yu,Crozier, Stuart,MRI Coil Design Using Boundary-Element Method With Regularization Technique: A Numerical Calculation Study,IEEE Transactions on Magnetics,2010,46(4):1052~1059
52. Lu, Luyao,Xia, Ling,Ye, Xuesong,Cheng, Heping,Simulation of the effect of rogue ryanodine receptors on a calcium wave in ventricular myocytes with heart failure,Physical Biology,2010,7(2):1~11
53. Shou, Guofa,Xia, Ling,Jiang, Mingfeng,Wei, Qing,Liu, Feng,Crozier, Stuart,Solving the ECG Forward Problem by Means of Standard h- and h-Hierarchical Adaptive Linear Boundary Element Method: Comparison With Two Refinement Schemes,IEEE Transactions on Biomedical Engineering,2009,56(5):1454~1464
54. Dou, Jianhong,Xia, Ling,Zhang, Yu,Shou, Guofa,Wei, Qing,Liu, Feng,Crozier, Stuart,Mechanical analysis of congestive heart failure caused by bundle branch block based on an electromechanical canine heart model,Physics in Medicine and Biology,2009,54(2):353~371
55. Jiang, Mingfeng,Xia, Ling,Huang, Wenqing,Shou, Guofa,Liu, Feng,Crozier, Stuart,The application of subspace preconditioned LSQR algorithm for solving the electrocardiography inverse problem,Medical Engineering & Physics,2009,31(8):979~985
56. Jiang, Mingfeng,Xia, Ling,Shou, Guofa,Wei, Qing,Liu, Feng,Crozier, Stuart,Effect of Cardiac Motion on Solution of the Electrocardiography Inverse Problem,IEEE Transactions on Biomedical Engineering,2009,56(4):923~931
57. Guofa Shou, Ling Xia, Mingfeng Jiang, Qing Wei, Feng Liu and Stuart Crozier, Truncated total least squares (TTLS): a new regularization method for the solution of ECG inverse problems, IEEE Transactions on Biomedical Engineering, Vol.55, 1327-1335, 2008.
58. Mingfeng Jiang, Ling Xia, Guofa Shou, Feng Liu and Stuart Crozier, Two hybrid regularization frameworks for solving the electrocardiography inverse problem, Physics in Medicine and Biology, Vol.53, 5151-5164, 2008.
59. Mingfeng Jiang, Ling Xia, Guofa Shou and Min Tang, Combination of the LSQR method and a genetic algorithm for solving the electrocardiography inverse problem, Physics in Medicine and Biology, Vol.52, 1277-1294, 2007.
60. Yu Zhang, Ling Xia, Yinglan Gong, Jianhong Dou, Efficient numerical methods for solving the membrane equations of human ventricular cell model, Journal of Computational and Theoretical Nanoscience, Vol.4, 1-5, 2007.
61. Yu Zhang, Ling Xia, Yinglan Gong,Application of Efficient Numerical Methods in Solution of Ordinary Differential Equations for Modeling Electrical Activity in Cardiac Cells,Communications in Computer and Information Science, Vo.2, 432-441, 2007.
62. Mingfeng Jiang, Ling Xia, Guofa Shou,Combining Regularization Frameworks for Solving the Electrocardiography Inverse Problem, Communications in Computer and Information Science, Vo.2, 1210-1219, 2007.
63. Yu Zhang, Ling Xia, Yinglan Gong, Ligang Chen, Guanghuan Hou and Min Tang, Parallel Solution in Simulation of Cardiac Excitation Anisotropic Propagation, Lecture Notes in Computer Science, Vol. 4466, 170-179, 2007.
64. Guofa Shou, Ling Xia, Mingfeng Jiang, Forward and inverse solutions of electrocardiography problem using an adaptive BEM method, Lecture Notes in Computer Science, Vol. 4466, 290-299, 2007.
65. Mingfeng Jiang, Ling Xia, Guofa Shou,Noninvasive electroardiographic imaging: application of hybrid Methods for solving the electrocardiography inverse problem, Lecture Notes in Computer Science, Vol. 4466, 269-279, 2007.
66. Ling Xia, Yu Zhang, Henggui Zhang, Qing Wei, Feng Liu and Stuart Crozier, Simulation of Brugada syndrome using cellular and three-dimensional whole-heart modeling approaches,Physiological Measurement, Vol.27, 1125–1142, 2006.
67. Ling Xia, Meimei Huo, Qing Wei, Feng Liu and Stuart Crozier, Electrodynamic Heart Model Construction and ECG Simulation,Methods of Information in Medicine, Vol.45, 564-573, 2006.
68. Qing Wei, Feng Liu, Ben Appleton, Ling Xia, Nianjun Liu, Stephen Wilson, Robyn Riley, Wendy Strugnel, Richard Slaughter, Russel Denman and Stuart Crozier, Effect of cardiac motion on body surface electrocardiographic potentials:an MRI-based simulation study,Physics in Medicine and Biology, Vol.51, 3405-3418, 2006.
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