崔小强，1974年10月出生于吉林省梨树县。

1974 年10 月出生于吉林省梨树县。1997年7月毕业于吉林大学化学系应用化学专业，获理学学士学位。

1997年9月进入长春应用化学研究所电分析化学国家重点实验室学习，2002年12月获分析化学理学博士学位(导师：杨秀荣研究员)，论文题目为“表面等离子体共振技术研究生物分子之间的相互作用”。之后作为助理研究员，在长春应用化学研究所从事研究工作。

2005年6 -10月前往法国格勒诺布尔第一大学，从事生物传感器的合作研究(PI: Prof. Serge Cosnier)。2005年12月进入新加坡南洋理工大学生物医学工程系，生物纳米技术研究组从事博士后研究工作（PI: Prof. Chang Ming Li）。

研究方向为纳米材料合成、电化学传感器的开发，及表面等离激元共振生物传感技术的应用；2008年4月加入日本产业技术综合研究所(AIST),作为博士后特别研究员（PI: Prof. Junji Nishii & Dr. Keiko Tawa），从事纳/微米周期结构耦合的金属表面等离激元共振材料（Plasmonic materials）的创制及其在生物检测中的应用研究。2010年，作为引进学术带头人进入吉林大学材料科学与工程学院工作。

作为主要完成人员，曾参与完成了国内外多个基金项目。包括：

双电层电容生物大分子传感器的研制和应用（负责人：杨秀荣，批准号：29845002），国家自然科学基金委仪器专项项目。

表面等离子体共振，电化学实时研究生物大分子相互作用（负责人：杨秀荣，批准号：20075027），自然科学基金面上项目。

癌症早期诊断标志物的实时分析（负责人：汪尔康，批准号：20335040），自然科学基金重点项目。

光-分子强结合反应场的创成，2007-2011年，日本文部省特定领域研究。Singapore DSO (Defence Science Organization) under grant contract DSOCL04135 (Prof. Changming Li) The development of a miniaturized electrochemical sensor on a MEMS platform, DSO, 272000。新加坡。Singapore ASTAR grant under contract No. 052 117 0031 (Prof. Changming Li) Nanoscale organic transistor by web printing process。新加坡。

2. 国家自然科学基金委面上基金项目“高通量荧光增强生物芯片的纳米周期结构制造”，No.21275064，78万，2013.1-2016.12；

2. 国家自然科学基金面上项目“新型表面等离激元共振材料及其生物传感芯片的研制”， NO.21075051，35万,2011.1-2013.12；

3. 横向课题，“无酶型纳米电化学葡萄糖传感器的研发”，50万，2010.11-2012.11；

4. 中国科学院长春应用化学研究所电分析化学国家重点实验室开放课题，“基于纳米材料的电化学葡萄糖传感器的研究”，6万，2011.1-2013-12

主要研究领域：表面等离激元共振技术；生物传感器；纳米材料；生物分析化学；光谱增强；电分析化学等方面的研究。

在国内外期刊上发表SCI收录学术论文61篇（第一作者12 篇，第二作者18 篇，通讯作者13篇）；H因子=22；论文被他人引用超过1514次，其中3篇论文单篇他人引用超过100次。参加国际会议6次，发表国际会议论文13篇。

2002年12月，博士

中国科学院长春应用化学研究所，电分析化学国家重点实验室

论文题目：表面等离子体共振技术研究生物分子间相互作用

导师：杨秀荣研究员

(Ph. D. in Analytical Chemistry, December 2002 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China Dissertation: Biomolecular interaction analysis by using surface plasmon resonance (SPR) technique)

1997年6月，本科

吉林大学化学系，应用化学专业

(B.S. in Applied Chemistry, June 1997 Department of Chemistry, Jilin University Thesis: Electrochemical behavior of porphyrin derivatives)

PROFESSIONALEMPLOYMENT

2010.04，吉林大学，材料科学与工程学院, 教授

(April 2010 – present, Professor in School of Materials Science and Engineering, Jilin University)

2008.04 –2010.03, 日本, 产业技术综合研究所，细胞工程部, 特别研究员

(April 2008–March 2010, Research Staff in Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan)

2005.12 –2008.03, 新加坡，南洋理工大学，生物工程系，博士后

(December 2005 – March 2008, Postdoctoral Research Fellow in Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore)

2005.06 –2005.10, 法国，格勒诺布尔第一大学，电化学实验室，合作研究

(June 2005 – October 2005, Visiting research scientist in Laboratoire d'Electrochimie Organique et de Photochimie Redox, Institut de Chimie Moléculaire de Grenoble, Université Joseph Fourier, Grenoble, France)

2003.06 –2005.12，中国科学院长春应用化学研究所，电分析化学国家重点实验室，助理研究员

(June 2003 – December 2005, Research Associate in Bioanalysis Research Group, State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, China)

RESEARCHEXPERIENCES

I. April 2008 – Present AIST, Osaka, Japan

a. Studies of plasmonic nanomaterial enhanced fluorescence

(1) Develop tailored one dimensional plasmonic gratings for enhanced fluorescence detection and microscopic imaging. The influence of depth and duty ratio on grating-coupled surface plasmon polaritons.

(2) Plasmonic nanohole arrays metalized by silver for fluorescence enhancement microscopic observation: improvement from one dimensional to two dimensional excitation.

b. Studies of the coupling of AuNPs with grating surface

(1) Multilayer assembly of metal nanoparticles on quartz gratings and their plasmonic coupling properties

(2) Spacer controlled the interaction between localized SPR of nanoparticles and propagated SPR of silver grating.

II. December 2005 – March 2008 Nanyang Technological University, Singapore

a. Studies of electrochemical biosensor

(1) Highly sensitive lactate biosensor by engineering chitosan/PVI-Os/CNT/LOD network nanocomposite

(2) Electrochemical synthesis conductive polymer (e.g., polyaniline and polypyrrole) nanostructures and their application

b.Studies of bionanotechnology: nanoparticles synthesis and application

(1) biocatalytic generation of ppy-enzyme-CNT nanocomposite and their application in biosensors

(2) In-situ photoreduction synthesis of silver nanostructures and their application in localized surface plasmon resonance (LSPR) biosensor and surface Raman enhanced scattering (SERS)

(3) Synthesis and application of semiconductor nanowires (Bi2S3) in photovoltaic devices.

c.Studies of ultrathin multilayer assembly

(1) Layer-by-layer assembly of hyaluronan/PDDA for silver nanoarrays

(2) pH-controlled construction of chitosan/alginate multilayer film for antibody loading

(3) Covalently linked DNA/protein multilayered film for controlled DNA release

III.June 2005 – October 2005 Universityof Joseph Fourier, Grenoble, France

Studies of electrochemical enzyme biosensor

Specific determination of As(V) by an acid phosphatase-polyphenol oxidase biosensor

IV.June 2003 – May 2005 Changchun Institute of Applied Chemistry, China

Studies of the synthesis of nanomaterials

(1) Biomolecules assistant synthesis Au and Ag nanoparticles

(2) Morphology-controlled synthesis of ZnO trough under mild conditions

V. September 1997 – December 2002 Changchun Institute of Applied Chemistry, China

a.Studies of theapplication of surface plasmon resonance (SPR) for bioanalysis.

(1) Direct immunoassay of human serum albumin

(2) Sandwich immunoassay of IgG and ferritin protein in serum

(3) Competition immunoassay of small molecular morphine

(4) Kinetic analysis of TNF immune complex

(5) Interaction of low molecular weight chitosan with mimic membrane

b.Studies of layer-by-layer assembly of biomolecules

(1) Biotinlyted IgG/streptavidin multilayers characterization and application in biosensing

(2) PEI/DNA multilayers construction and characterization

(3) New sensor chip surface modification method for histone-DNA interaction analysis.

PUBLICATIONS(H-index: 22; Total cited 1575 times till April, 2014)

1. X. Q. Cui, K. Tawa, K. Kintaka & J. Nishii, Enhanced Fluorescence Microscopic Imaging by Plasmonic Nanostructrues: From a 1D Grating to a 2D Nanohole Array. Advanced Functional Materials, 2010, 20, 945.

2. X. Q. Cui, K. Tawa, H. Hori & J. Nishii, Tailored plasmonic gratings for enhanced fluorescence detection and microscopic imaging. Advanced Functional Materials,2010, 20, 546-553.

3. X. Q. Cui, K. Tawa, H. Hori & J. Nishii, Duty ratio-dependent fluorescence enhancement in Ag-coated grating-coupled surface plasmon polaritons. Applied Physics Letters,2009, 95, 133117.

4. X. Q. Cui, C. M. Li, H. F. Bao, X. T. Zheng, J. F. Zang, C. P. Ooi & J. Guo, Hyaluronan-assisted photoreduction synthesis of silver nanostructures: From nanoparticle to nanoplate. Journal of Physical Chemistry C,2008,112,10730-10734.

5. X. Q. Cui, C. M. Li, H. F. Bao, X. T. Zheng & Z. S. Lu, In situ fabrication of silver nanoarrays in hyaluronan/PDDA layer-by-layer assembled structure. Journal of Colloid and Interface Science,2008,327,459-465.

6. X. Q. Cui, C. M. Li, J. F. Zang, Q. Zhou, Y. Gan, H. F. Bao, J. Guo, V. S. Lee & S. M. Moochhala, Biocatalytic generation of ppy-enzyme-CNT nanocomposite: From network assembly to film growth. Journal of Physical Chemistry C,2007,111,2025-2031.

7. X. Q. Cui, C. M. Li, J. F. Zang & S. C. Yu, Highly sensitive lactate biosensor by engineering chitosan/PVI-Os/CNT/LOD network nanocomposite. Biosensors & Bioelectronics,2007,22,3288-3292.

8. X. Q. Cui, F. Yang, A. X. Li & X. R. Yang, Chip surface charge switch for studying histone-DNA interaction by surface plasmon resonance biosensor. Analytical Biochemistry,2005,342,173-175.

9. X. Q. Cui, Y. F. Sha, F. Yang, P. Yu, J. N. Li & X. R. Yang, Detection of ferritin by surface plasmon resonance under mass transport-limited. Chinese Journal of Analytical Chemistry,2005,33,1639-1642.

10. X. Q. Cui, F. Yang, Y. F. Sha & X. R. Yang, Real-time immunoassay of ferritin using surface plasmon resonance biosensor. Talanta,2003,60,53-61.

11. X. Q. Cui, R. J. Pei, X. Z. Wang, F. Yang, Y. Ma, S. J. Dong & X. R. Yang, Layer-by-layer assembly of multilayer films composed of avidin and biotin-labeled antibody for immunosensing. Biosensors & Bioelectronics,2003,18,59-67.

12. X. Q. Cui, R. J. Pei & X. R. Yang, Detection of anti-human serum albumin antibody using surface plasmon resonance biosensor. Chinese Journal of Analytical Chemistry, 2000,28,950-955.

13. W. Wang, C. Yang, X. Q. Cui,Q. L. Bao, C. M. Li, Droplet microfluidic preparation of au nanoparticles-coated chitosan microbeads for flow-through surface-enhanced Raman scattering detection.Microfluidics and Nanofluidics,2010, 9, 1175-1183.

14. H. F. Bao, Z. S. Lu, X. Q. Cui,Y. Qao, J. Guo, J. M. Anderson, C. M. Li, Extracellular microbial synthesis of biocompatible CdTe quantum dots, ActaBiomaterials, 2010, 3534-3541.

15. R. Li, X. Q. Cui,W. H. Hu, Z. S. Lu, C. M. Li, Fabrication of Oriented Poly-L-lysine/Bacteriorhodopsin-embedded Purple Membrane Multilayer Structure for Enhanced Photoelectric Response, Journal of Colloid and Interface Science,2010, 344, 150-157.

16. A. X. Li, X. Q. Cui, F. Yang & X. R. Yang, Interaction between F-Actin and Negatively Charged Lipids Membrane. Chinese Journal of Analytical Chemistry,2009,37,25-29.

17. J. F. Zang, C. M. Li, S. J. Bao, X. Q. Cui, Q. L. Bao & C. Q. Sun, Template-free electrochemical synthesis of superhydrophilic polypyrrole nanofiber network. Macromolecules,2008,41,7053-7057.

18. J. F. Zang, S. J. Bao, C. M. Li, H. J. Bian, X. Q. Cui, Q. L. Bao, C. Q. Sun, J. Guo & K. R. Lian, Well-aligned cone-shaped nanostructure of polypyrrole/RuO2and its electrochemical supercapacitor. Journal of Physical Chemistry C,2008,112,14843-14847.

19. Y. Qiao, S. J. Bao, C. M. Li, X. Q. Cui, Z. S. Lu & J. Guo, Nanostructured polyanifine/titanium dioxide composite anode for microbial fuel cells. Acs Nano,2008,2,113-119.

20. S. J. Bao, C. M. Li, J. F. Zang, X. Q. Cui, Y. Qiao & J. Guo, New nanostructured TiO2for direct electrochemistry and glucose sensor applications. Advanced Functional Materials,2008,18,591-599.

21. H. F. Bao, C. M. Li, X. Q. Cui, Q. L. Song, H. B. Yang & J. Guo, Single-crystalline Bi2S3nanowire network film and its optical switches. Nanotechnology,2008,19.

22. H. F. Bao, C. M. Li, X. Q. Cui, Y. Gan, Q. L. Song & J. Guo, Synthesis of a highly ordered single-crystalline Bi2S3nanowire array and its metal/semiconductor/metal back-to-back Schottky diode. Small,2008,4,1125-1129.

23. Q. Zhou, C. M. Li, J. Li, X. Q. Cui& D. Gervasio, Template-synthesized cobalt Porphyrin/Polypyrrole nanocomposite and its electrocatalysis for oxygen reduction in neutral medium. Journal of Physical Chemistry C,2007,111,11216-11222.

24. J. F. Zang, C. M. Li, X. Q. Cui, J. X. Wang, X. W. Sun, H. Dong & C. Q. Sun, Tailoring zinc oxide nanowires for high performance amperometric glucose sensor. Electroanalysis,2007,19,1008-1014.

25. W. Y. Yuan, H. Dong, C. M. Li, X. Q. Cui, L. Yu, Z. S. Lu & Q. Zhou, pH-Controlled construction of chitosan/alginate multilayer film: Characterization and application for antibody immobilization. Langmuir,2007,23,13046-13052.

26. Z. S. Lu, C. M. Li, Q. Zhou, Q. L. Bao & X. Q. Cui,Covalently linked DNA/protein multilayered film for controlled DNA release. Journal of Colloid and Interface Science,2007,314,80-88.

27. W. H. Hu, C. M. Li, X. Q. Cui, H. Dong & Q. Zhou, In situ studies of protein adsorptions on poly(pyrrole-co-pyrrole propylic acid) film by electrochemical surface plasmon resonance. Langmuir,2007,23,2761-2767.

28. H. F. Bao, X. Q. Cui, C. M. Li & J. F. Zang, Shape-controlled assembly of luminescent dumbbell-like CdTe-cystine nanocomposites. Nanotechnology,2007,18.

29. H. F. Bao, X. Q. Cui, C. M. Li, Q. L. Song, Z. S. Lu & J. Guo, Synthesis and electrical transport properties of single-crystal antimony sulfide nanowires. Journal of Physical Chemistry C,2007,111,17131-17135.

30. H. F. Bao, X. Q. Cui, C. M. Li, Y. Gan, J. Zhang & J. Guo, Photoswitchable semiconductor bismuth sulfide (Bi2S3) nanowires and their self-supported nanowire arrays. Journal of Physical Chemistry C,2007,111,12279-12283.

31. S. Cosnier, C. Mousty, X. Q. Cui, X. R. Yang & S. J. Dong, Specific determination of As(V) by an acid phosphatase-polyphenol oxidase biosensor. Analytical Chemistry,2006,78,4985-4989.

32. P. Yu, B. Qi, X. Q. Cui, F. Yang, J. N. Li & X. R. Yang, Direct electrochemistry of horse spleen ferritin on modified gold electrode. Chinese Journal of Analytical Chemistry,2005,33,1239-1242.

33. P. Yu, X. Q. Cui, F. Yang, J. N. Li & X. R. Yang, Progress on studying biomembrane by surface plasmon resonance technique. Chinese Journal of Analytical Chemistry,2005,33,575-579.

34. J. Tang, X. Q. Cui, Y. Liu & X. R. Yang, Morphology-controlled synthesis of monodisperse ZnO troughs at the air-water interface under mild conditions. Journal of Physical Chemistry B,2005,109,22244-22249.

35. Q. Gao, X. Q. Cui, F. Yang, Y. Ma & X. R. Yang, Preparation of poly(thionine) modified screen-printed carbon electrode and its application to determine NADH in flow injection analysis system. Biosensors & Bioelectronics,2003,19,277-282.

36. S. H. Chen, X. Q. Cui, F. Yang, Y. N. Ni & X. R. Yang, Kinetic characteristics of the interaction between morphine and its antibody by SPR competitive immunoassay. Chemical Journal of Chinese Universities-Chinese,2003,24,1770-1774.

37. F. Yang, X. Q. Cui, X. R. Yang, T. Chen & J. Lu, Kinetic analysis of TNF immune complex by using surface plasmon resonane. Chemical Journal of Chinese Universities-Chinese,2002,23,382-384.

38. F. Yang, X. Q. Cui& X. R. Yang, Interaction of low-molecular-weight chitosan with mimic membrane studied by electrochemical methods and surface plasmon resonance. Biophysical Chemistry,2002,99,99-106.

39. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Layer-by-layer assembly of multilayer films composed of streptavidin and biotinylated antibody by real-time biomolecular interaction analysis. Chemical Journal of Chinese Universities-Chinese,2002,23,195-198.

40. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Amplified immunoassay of human IgG using real-time biomolecular interaction analysis (BIA) technology. Chinese Journal of Chemistry,2002,20,441-446.

41. W. G. Li, X. Q. Cui, X. R. Yang, D. Q. Zhao & J. Z. Ni, Real-time analysis of the interaction between calmodulin and melittin by SPR spectroscopy. Chinese Chemical Letters,2002,13,165-166.

42. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Electrostatic layer-by-layer assembly of polycation and DNA multilayer films by real-time surface plasmon resonance technique. Chinese Journal of Chemistry,2001,19,433-435.

43. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Studies on electrostatic adsorption of proteins on modified surface by real-time surface plasmon resonance technique. Chemical Journal of Chinese Universities-Chinese,2001,22,1128-1130.

44. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption. Biomacromolecules,2001,2,463-468.

45. R. J. Pei, X. Q. Cui, X. R. Yang & E. K. Wang, Real-time immunoassay of antibody activity in serum by surface plasmon resonance biosensor. Talanta,2000,53,481-488. (IF= 3.206)CONFERENCE PAPERS AND PRESENTATIONS:1. Xiaoqiang Cui, Keiko Tawa, Junji Nishii, Grating coupled surface plasmon resonance enhanced fluorescence and its application for cell observation, 2009 MRS Fall Meeting, O18.12, Nov. 30 – Dec. 4, 2009, Boston, MA, USA, Poster2. Xiaoqiang Cui, Changming Li, Hyaluronan-Mediated In-Situ Synthesis of Ag Nanostructures by UV-Irradiation and Their Application in Surface-Enhanced Raman Scattering, International Conference on Cellular & Molecular Bioengineering, Dec. 10-12, 2007, Singaproe, Oral presentation3. Xiaoqiang Cui, Fan Yang, Yufang Sha, and Xiurong Yang, Real-Time Sandwich Enhancement Immunoassay of Ferritin Using BIAcore Biosensor, Ninth International Seminar on Electroanalytical Chemistry, Oct. 10-12, 2003, Changchun, China, P141, Poster 4. Xiaoqiang Cui, Fan Yang, Xiurong Yang. Real-Time Study on the Interaction Between Protein and Polyelectrolyte by Surface Plasmon Resonance, Eighth International Seminar on Electroanalytical Chemistry, Oct. 14-16,2001, Changchun, China, P239, Poster 5. Xiaoqiang Cui, Fan Yang, Xiurong Yang. A New Substrate for Study the Interaction Between Histone Protein and DNA by Real-time BIA,Eighth International Seminar on Electroanalytical Chemistry, Oct. 14-16, 2001, Changchun, China, P241, Poster 6. Xiaoqiang Cui, Renjun Pei, Fan Yang, Xiurong Yang. Layer-by-layer Assembly of Multilayer Films of Streptavidin and Biotinylated Antibody, Ninth Beijing Conference and Exhibition on Instrumental Analysis, Oct. 17-20, 2001, Beijing, China F113, Poster 7. Xiaoqiang Cui, Renjun Pei, Xiurong Yang. Detection of Anti-human Serum Albumin Antibody Using Surface Plasmon Resonance Biosensor, Eighth Beijing Conference and Exhibition on Instrumental Analysis, Oct. 25-27, 1999, Beijing, China, F137, Poster 8. Xiurong Yang, Xiaoqiang Cui, Fan Yang, Shouhui Chen, Yongnian Ni, Kinetic Investigation of the Molecular Interaction by Surface Plasmon Resonance (SPR), Ninth International Seminar on Electroanalytical Chemistry, Oct. 10-12, 2003, Changchun, China, P24, Poster 9. Fan Yang, Xiaoqiang Cui, Xiurong Yang. Real time study on the interaction between trypsin and trypsin inhibitors by surface plasmon resonance, Eighth International Seminar on Electroanalytical Chemistry, Oct. 14-16, 2001, Changchun, China, P237, Poster 10. Fan Yang, Xiaoqiang Cui, Xiurong Yang, Real-Time Study of Interaction between Protein and Lipopolysaccharide, Ninth International Seminar on Electroanalytical Chemistry, Oct. 10-12, 2003, Changchun, China, P139, Poster11. Xiurong Yang, Renjun Pei,Xiaoqiang Cui. Real-time Immunoassay by Surface Plasmon Resonance Biosensors, Seventh International Seminar on Electroanalytical Chemistry, Oct. 22-24, 1999, Changchun, China, P61, Poster12. Xiurong Yang, Fan Yang, Xiaoqiang Cui. Study of the TNFα Molecular Interaction Analysis in Real Time by SPR,, Eighth International Seminar on Electroanalytical Chemistry, Oct. 14-16, 2001, Changchun, China, P14, Poster13. Fan Yang, Zhiliang Cheng, Xiaoqiang Cui, and Xiurong Yang, Detection of PCR Products By Surface Plasmon Resonance, Eighth Beijing Conference and Exhibition on Instrumental Analysis, Oct. 25-27, 1999, Beijing, China,F141, Poster