袁直_国家基金委材料学部评审委员

袁直

国家基金委材料学部评审委员

袁直，毕业于南开大学，博士。民盟成员。国家基金委材料学部评审委员，天津市重大科技攻关项目、产业化项目评审专家。2000年入选教育部跨世纪优秀青年培养计划，天津市“131”工程第一层次培养计划。

人物经历

1989年获博士学位后留南开大学高分子所任讲师，1992年晋升为副教授，1996年晋升为教授。2000年7月，任南开大学化学院副院长，高分子所所长。

现任南开大学化学院副院长，高分子所所长，民盟天津市委副主任委员。

2017年6月，民盟天津市第十一届委会召开第一次全体会议，选举袁直为副主任委员。

第十三届全国政协委员

研究方向

1、吸附分离材料的结构设计及吸附机制研究

2、纳米肝靶向给药系统研究

3、诱导抗凝血生物化表面的设计和构建

主要贡献

国家自然科学基金重点项目及多项面上项目，“973项目”课题，天津市科技支撑重点项目，天津市自然科学基金重点项目。

部分论文（原文）

(1) Zhi Yuan*. Doxorubicin-loadedglycyrrhetinicacid-modified alginate nanoparticles for liver tumor chemotherapy. Biomaterials, 2012, 33, 2187–2196.

(2) ZhiYuan*. Self-assembly and liver targeting of sulfatedchitosan nanoparticlesfunctionalized with glycyrrhetinic acid. Nanomedicine: nanotechnology, biology, and medicine, 2012,8, 870–9.

(3) ZhiYuan*. Synthetic receptor and its association with CTDpeptides. Tetrahedron, 2012, 68, 2357–2362.

(4) ZhiYuan*. In vitro evaluation of polymeric micelles basedonhydrophobically-modified sulfated chitosan as a carrier of doxorubicin. Journal of Materials Science: Materials in Medicine, 2012, 23,1663–1674.

(5) ZhiYuan*. Selective removal of caffeine from tea extracts using macroporouscrosslinked polyvinyl alcohol adsorbents. Journal of Separation Science, 2012, 35, 36–44.

(6) ZhiYuan*. Effects of oligopeptide’s conformational changes on itsadsorption. Colloids andsurfaces. B,Biointerfaces, 2011, 83,229–236.

(7) ZhiYuan*. HUVEC cell affinity evaluation and integrin-mediated mechanismstudy on PHSRN-modified polymer. Colloidsand surfaces B Biointerfaces, 2011, 84,6–12.

(8) ZhiYuan*. A comparison study between polymeric ligand and monomeric ligandfor oligopeptide adsorption. Journalofcolloid and interface science, 2011, 355, 478–85.

(9) ZhiYuan*. Glycyrrhetinic acid-functionalized degradable micelles asliver-targeted drug carrier. Journalof Materials Science-Materials in Medicine, 2011,22, 853–863.

(10) ZhiYuan*. An efficient molecular docking method for adsorbentscreening. Journal OfChromatography B, 2011, 879,1605–1609.

(11) Wang, J.; Wang, W.;Wei, Q.; Zhang, S.;Yuan, Z. New method for affinity adsorbent screening usinggold colloids. Langmuir, 2011,27, 11457–65.

(12) ZhiYuan*. Understanding the role of the C3-hydroxyl group inglycyrrhetinicacid on liver targeting. Journalof controlled release, 2011,152, 237–239.

(13) ZhiYuan*. Antitumor activity of drug loaded glycyrrhetinicacid modifiedalginate nanoparticles on mice bearing orthotopic liver tumor. Journal of controlled release, 2011, 152, 111–113.

(14) ZhiYuan*. The potential for blood vessel engineering of PHSRN-modifiedpolymer:HUVEC cell affinity evaluation and integrin-mediated mechanismstudy. Journal of controlledrelease, 2011, 152, 243–245.

(15) ZhiYuan*. Blood compatibility evaluation of poly(D,L-lactide-co-beta-malicacid) modified with the GRGDS sequence. Colloids and surfaces. B, Biointerfaces, 2010, 75, 370–6.

(16) Tian, Q.; Zhang,C.-N.; Wang, X.-H.; Wang,W.; Huang, W.; Cha, R.-T.; Wang, C.-H.; Yuan, Z.; Liu,M.; Wan, H.-Y.; Tang, H.Glycyrrhetinic acid-modified chitosan/poly(ethyleneglycol) nanoparticles for liver-targeted delivery. Biomaterials, 2010, 31, 4748–4756.

(17) ZhiYuan*. Adsorbents with high selectivity for uremic middle molecularpeptides containing the Asp-Phe-Leu-Ala-Glusequence. Langmuir, 2010,26, 7181–7187.

(18) ZhiYuan*. Colorimetric detection of bis-phosphorylated peptides usingzinc(ii) dipicolylamine-appended gold nanoparticles. Sensors and Actuators B: Chemical, 2010, 147, 687–690.

(19) ZhiYuan*. Glycyrrhetinicacid-modified poly(ethylene glycol)-b-poly(gamma-benzyll-glutamate) micelles for liver targeting therapy. Acta biomaterialia, 2010, 6,3927–3935.

(20) ZhiYuan*. Silk fibroin/montmorillonite nanocomposites: effect of pH on theconformational transition and clay dispersion. Biomacromolecules, 2010,11, 1796–1801.

(21) ZhiYuan*. Insight into glycyrrhetinic acid: the role of the hydroxyl group onliver targeting. Internationaljournal of pharmaceutics, 2010,400, 153–7.

(22) ZhiYuan*. Design, optimization and evaluation of specific affinity adsorbent foroligopeptides. Journal ofChromatography A, 2010, 1217, 7539–7546.

(23) ZhiYuan*. A novel copolymer poly(lactide-co-beta-malic acid) with extendedcarboxyl arms offering better cell affinity and hemacompatibility for bloodvessel engineering. Tissue engineeringPart A, 2009, 15, 65–73.

(24) ZhiYuan*. Affinity adsorption mechanis mstudies of adsorbents foroligopeptides using model polymer. Polymer, 2009,50, 1602–1608.

(25) ZhiYuan*. Rapid and efficient screening of adsorbent for oligopeptide usingmolecular docking and isothermal titration calorimetry. Journal of Separation Science, 2009, 32, 2462–2468.

(26) ZhiYuan*. Synthesis, degradability, and cell affinity ofpoly(DL-lactide-co-RS-hydroxyethyl-beta-malolactonate). Journal of Biomedical Materials Research Part A, 2008, 87, 459–469.

(27) ZhiYuan*. Studies on adsorption isotherms of endotoxin and BSA using anaffinity column. ProcessBiochemistry, 2007, 42, 285–288.

(28) ZhiYuan*. Studies on endotoxin removal mechanism of adsorbents with aminoacid ligands. Journal OfChromatography B, 2007, 852, 288–292.

(29) ZhiYuan*. Adsorption mechanism at the molecularlevel between polymers anduremic octapeptide by the 2D 1H NMR Technique. Biomacromolecules, 2006, 7, 1811–1818.

(30) ZhiYuan*. Synthesis and characterization of a functionalized amphiphilicdiblock copolymer: MePEG-b-poly(DL-lactide-co-RS-β-malic acid). Colloid and Polymer Science, 2006, 285, 273–281.

(31) ZhiYuan*. Synthesis and characterization of novel functionalized polylactideswith pendent hydroxyl arms. Polymer, 2006, 47, 6978–6985.

(32) ZhiYuan*. Endotoxin adsorbent using dimethylamine ligands. Biomaterials, 2005,26, 2741–7.

(33) ZhiYuan*. Separation, identification of uremic middle molecules, andpreliminary study ontheir toxicity. Clinica chimica acta, 2004, 350,89–98.

专利

1. 袁直等, 中国发明专利, ZL 93107357.x。

2. 袁直等, 中国发明专利, ZL 93107356.1。

3. 袁直等, 中国发明专利, ZL 03 144231.5。

4. 袁直等, 中国发明专利, ZL 03 144383.4。

5. 袁直等, 中国发明专利, ZL200510015172.7。

6. 袁直等, 中国发明专利, ZL 200810052636.5。

7. 袁直等, 中国发明专利, ZL 200810052635.0,。

8. 袁直等, 中国发明专利, CN101444720。