人物经历
罗杰,男,
博士,
教授。长期从事植物次生代谢调控及代谢组学研究。2002年博士毕业于华中科技大学
植物生物技术专业。2003-2008年在英国著名研究所John Innes Centre从事访问及博士后研究。
1989-1994:
湖北工业大学 食品工程 学士;
1994-1997: 大连轻工业大学
微生物工程 硕士;
1998-2002:
华中科技大学 植物生物技术 博士。
职 历
1997-2008
华中科技大学生命科学与技术学院,先后任讲师,副教授;
2003-2008 英国John Innes Centre,先后从事访问及博士后研究;
现担任湖北省生化与分子生物学会常务理事、中国生化与分子生物学会农业分会理事、湖北省遗传学会理事、植物学报编委、Scientific Data(Nature系列)编委。
研究方向
代谢物作为植物与环境相互适应的最直接的因素,因其本身种类的繁多和数量的庞大而具有极为丰富的自然变异。代谢组学作为
系统生物学的重要分支,是20世纪90年代末期发展起来的一门新兴学科,近年来在植物研究领域受到广泛关注,并取得了一系列重要进展。据估计,地球上存在超过40万种植物,并且所有植物代谢产物大约有20万到100万种,这意味着植物代谢物的应用具有巨大的潜力,特别是天然产物药物研究,将极大促进各种新药的开发和应用。
代谢组是基因与表型的桥梁。将基因组和表型组联系起来,利用基因组已有的大量数据,结合代谢组和
全基因组关联分析,进行代谢组的全基因组关联分析可以极大的推动我们对植物代谢组学的研究,增强对代谢组遗传基础的了解,这些认知可以促进我们对植物特别是
粮食作物进行相应的遗传改良,以便获得具有更好抗性、更高产量和品质的优异品种。
该课题组(作物代谢生物学,Crop Metabolic Biology)以水稻、玉米,柑橘等作物为材料,通过代谢组学研究,深化人们对代谢组遗传基础的理解,有助于搭建基因组和表型组之间的桥梁,同时对于
利用代谢工程进行营养品质改良具有积极意义。也可以为
功能基因组学研究提供一种高效、快速进行大规模基因功能鉴定的新方法,为作物逆境生理及营养品质形成机制研究和遗传改良实践提供新资源和新思路。
主要贡献
2009年加入
华中农业大学并入选教育部新世纪优秀人才资助计划,主持
国家自然科学基金、“
863”重点项目、“
973”课题等多项。2016年8月荣获“
国家杰出青年科学基金”资助。在Nature Genetics, Nature Biotechnology, Nature Communications, Plant Cell, PNAS, Current Opinion in Plant Biology, Plant Journal, Molecular Plant, Food Chemistry, Journal of Experimental Botany, Journal of Integrative Plant Biology,
生命科学和科技导报等主流期刊发表多篇高水平论文,申请并获批了国家发明专利多项。该研究为代谢组与功能基因组研究提供了新思路,新方向,并多次应邀在国际国内学术会议上做大会报告任教期间,主讲的《分子生物学》深受师生青睐,并入选国家级精品资源共享课程。
论著
1. Chen W, Wang W, Peng M, Gong L, Gao Y, Wan J, Wang S, Shi L, Zhou B, Li Z, Peng X, Yang C, Qu L, Liu X, Luo J*. Comparative and parallel genome-wide association studies for metabolic and agronomic traits in cereals. Nature Communication, 2016, In Press. (SCI, IF: 11.3).
2. Peng M, Gao Y, Chen W, Shen S, Shi J, Wang C, Zhang Y, Zou L, Wang S, Wan J, Liu X, Luo J*. Evolutionarily Distinct BAHD N-acyltransferases are Responsible for Natural Variation of Aromatic Amine Conjugates in Rice. Plant Cell, 2016, Vol.28: 1533–1550. (SCI, IF: 10.0).
3. Fang C, Zhang H, Wan J, Wu, Y, Li K, Jin C, Chen W, Wang S, Wang W, Zhang H, Zhang P, Zhang F, Qu L, Liu X, Zhou D, Luo J*. Control of Leaf Senescence by a MeOH-Jasmonates Cascade That Is Epigenetically Regulated by OsSRT1 in Rice.Molecular Plant, 2016, In Press. (SCI, IF: 7.1).
4. Qu L, Wu C, Zhang F, Wu Y, Fang C, Jin C, Liu X, Luo J*. Rice putative methyltransferase gene OsTSD2 is required for root development involving pectin modification. Journal of Experimental Botany, 2016, In Press. (SCI, IF: 5.7).
5. Jin C, Fang C, Yuan H, Wang S, Wu Y, Liu X, Zhang Y, Luo J*. Interaction between carbon metabolism and phosphate accumulation is revealed by a mutation of a cellulose synthase-like protein, CSLF6. Journal of Experimental Botany, 2015, 66(9):15-15. (SCI, IF: 5.7).
6. 刘贤青, 董学奎, 罗杰. 基于连锁与关联分析的植物代谢组学研究进展. 生命科学, 2015(8):986-994.
7. 刘贤青, 罗杰. 植物代谢组学技术研究进展. 科技导报, 2015(16):33-38.
8. Wang S, Tu H, Wan J, Chen W, Liu X, Luo J, Xu J, Zhang H. Spatio-temporal distribution and natural variation of metabolites in citrus fruits. Food Chemistry, 2015, 199:8-17. (SCI, IF: 4.1).
9.Luo J*. Metabolite-based genome-wide association studies in plants. Current Opinion in Plant Biology, 2015, 24: 31-38. (SCI, IF: 9.4).
10. Dong X, Gao Y, Chen W, Wang W, Gong L, Liu X, Luo J*. Spatio-temporal distribution of phenolamides and the genetics of natural variation of hydroxycinnamoyl spermidine in rice. Molecular Plant, 2015, 8: 111-121. (SCI, IF: 6.7).
11. Chen W, Gao Y, Xie W, Gong L, Lu K, Wang W, Li Y, Liu X, Zhang H, Dong H, Zhang W, Zhang L, Yu S, Wang G, Lian X*, Luo J*. Genome-wide association analyses provide genetic and biochemical insights into natural variation in rice metabolism. Nature Genetics, 2014, 46: 714-721. (SCI, IF: 31.6).
12. Dong X, Chen W, Wang W, Zhang H, Liu X, Luo J*. Comprehensive profiling and natural variation of flavonoids in rice. Journal of Integrative Plant Biology, 2014, 56: 876-886. (SCI, IF: 3.7).
13. Wen W, Li D, Li X, Gao Y, Li W, Li H, Liu J, Liu H, Chen W,Luo J*and Yan J*. Metabolome-based genome-wide association study of maize kernel leads to novel biochemical insights. Nature Communication, 2014, 5: 3438-3447. (SCI, IF: 10.2).
14. Gong L, Chen W, Gao Y, Liu X, Zhang H, Xu C, Yu S, Zhang Q*, Luo J*. Genetic analysis of the metabolome exemplified using a rice population. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110: 20320-20325. (SCI, IF: 9.4).
15. Chen W, Gong L, Guo Z, Wang W, Zhang H, Liu X, Yu S, Xiong L, Luo J*. A novel integrated method for large-scale detection, identification, and quantification of widely targeted metabolites: application in the study of rice metabolomics. Molecular Plant, 2013, 6: 1769-1780. (SCI, IF: 6.7).
16. Luo J, Fuell C, Parr A, Hill L, Elliott K, Michael AJ and Martin C.A novel spermidine acyltransferase responsible for the accumulation of polyamine conjugates in Aradidopsis seed. Plant Cell, 2009, 21(1): 318-333. (SCI, IF: 9.653) of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751).
17. Butelli E, Titta L, Giorgio M, Mock HP, Matros A, Peterek S, Schijlen EG, Hall RD, Bovy AG, Luo J, Martin C. Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nature Biotechnology, 2008, 26(11):1301-1308. (SCI, IF: 22.848) of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751).
18. Luo J, Butelli E, Hill L, Parr A, Niggeweg R, Bailey P, Weisshaar B, Martin C. AtMYB12 regulates caffeoyl quinic acid and flavonol synthesis in tomato; expression in fruit results in very high levels of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751) of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751).
19.Luo J, Nishiyama Y, Fuell C, Taguchi G et al.Convergent evolution in the BAHD family of acyl transferases: identification and characterization of anthocyanin acyl transferases from Arabidopsis thaliana. Plant Journal, 2007, 50(4): 678–695. (SCI, IF: 6.751) of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751).
20. Chang JL*, Luo J*, He GY. Regulation of accumulation of polyphenols by combined overexpression/silencing key enzymes of phyenylpropanoid pathway. Acta Biochimica et Biophysica Sinica, 2009,41(2): 123-130. (*, equal contribution) (SCI, IF: 1.017) of both types of polyphenol. Plant Journal, 2008,56(2): 316-326. (SCI, IF: 6.751).
21. Fang JY, Liu Y, Luo J, Wang YS, Shewry PR, He GY. Allelic variation and genetic diversity of high molecular weight glutenin subunit in Chinese endemic wheats (Triticum aestivumL.). Euphytica, 2009, 166(2): 177-182. (SCI, IF: 1.05).
22.Luo J, He GY. Optimization of elicitors and precursors for paclitaxel production in cell suspension culture of Taxus chinensisin the presence of nutrient feeding. Process Biochemistry, 2004, 39 (9): 1073-1079. (SCI, IF: 2.336).